Th17细胞／Treg细胞及其失衡在慢性自发性荨麻疹发病机制中的作用  

Roles of and imbalance between Thl7 and regulatory T cells in the pathogenesis of chronic spontaneous urticaria

作　　者：杨婧[1,2] 朱慧兰[1] 

机构地区：[1]广州市皮肤病防治所,510095 [2]广东医学院

出　　处：《国际皮肤性病学杂志》2012年第6期390-392,共3页International Journal of Dermatology and Venereology

基　　金：广东省自然科学基金面上项目（$2012020011077）;2009年广州市科技计划项目（200921一E011）

摘　　要：慢性自发性荨麻疹是一种常见的皮肤黏膜变态反应性疾病，以反复出现风团或红斑伴剧烈瘙痒为特征。介导免疫耐受的CD4＋CD25调节性T细胞和介导炎症反应的Thl7细胞是两类不同的CD4q＇细胞。两者数量此消彼长，功能拮抗，调节性T细胞和Thl7细胞数量和功能的平衡对维持免疫稳态起重要作用，失衡可引起免疫应答异常，导致包括慢性自发性荨麻疹在内的自身免疫性疾病的发生。初始CD4＋T细胞的细胞因子对他们之间的关系起到调节作用。Chronic spontaneous urticaria （CSU） is a common mucocutaneous allergic disease characterized by recurrent wheals and erythema with severe itching. The immunologic tolerance-mediating CD4~ CD25＋ regulatory T cells （Treg cells） and inflammation-mediating Th17 cells are two different kinds of CD4＋ T cells. There is a reciprocal relationship between Treg and Th17 cells in terms of number and function. The Treg/Th17 cell balance plays an essential role in the maintenance of immune homeostasis, and their imbalance may cause abnormal immune response, resulting in the occurrence of autoimmune diseases including CSU. The cytokine microenvironment around initial CD4＋ T cells exerts a regulatory role in the relationship between Th17 and Treg cells.

关 键 词：TH17细胞 T淋巴细胞 调节性 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]