宁夏地区变应性鼻炎与慢性鼻-鼻窦炎鼻息肉相关性研究  

The correlation study of allergic rhinitis and chronic rhinosinusitis with nasal polyps in Ningxia region

作　　者：马瑞霞[1] 底玲玲[1] 侯丽[1] 赵迪[1] 闫小会[1] 

机构地区：[1]宁夏医科大学总医院耳鼻咽喉头颈外科,银川750004

出　　处：《临床耳鼻咽喉头颈外科杂志》2012年第22期1030-1033,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家自然科学基金资助项目(No:81260157)

摘　　要：目的:探讨宁夏地区变应性鼻炎(AR)和慢性鼻-鼻窦炎鼻息肉的相关性。方法:将2009年01-12月期间就诊于我科的AR、慢性鼻-鼻窦炎鼻息肉、AR伴慢性鼻-鼻窦炎鼻息肉的116例患者进行分组,即实验组Ⅰ:(AR 46例)、实验组Ⅱ(慢性鼻-鼻窦炎鼻息肉46例)、实验组Ⅲ(AR伴慢性鼻-鼻窦炎鼻息肉24例),同时设正常对照组(31例);进行皮肤点刺试验,酶联免疫吸附试验检测血清特异性IgE浓度。结果:①特异性IgE分级主要集中在0、1、3级,以1级为主,各变应原特异性IgE阳性率排序不尽相同。实验组Ⅰ、Ⅱ、Ⅲ的特异性IgE总计阳性率分别为83.3%、75.0%、87.5%。②实验组Ⅰ、Ⅱ、Ⅲ的特异性IgE浓度分别为(10.33±2.12)、(8.43±2.23)、(15.28±2.16)kU/L;对照组特异性IgE浓度为(1.03±3.96)kU/L;实验组Ⅲ的特异性IgE浓度最高,实验组Ⅰ、Ⅱ、Ⅲ的特异性IgE浓度均明显高于对照组。结论:①本实验初步了解宁夏地区AR,慢性鼻-鼻窦炎鼻息肉特异性IgE分级主要集中在0～3级,以1级(即低级)为主,表明在宁夏地区AR和慢性鼻-鼻窦炎鼻息肉患者血清特异性IgE的浓度不是太高。艾蒿、德国小蠊、屋尘螨、花粉Ⅳ组变应原反应程度相对较强,是宁夏地区重要的变应原,应引起足够重视。②宁夏地区慢性鼻-鼻窦炎鼻息肉伴AR的比例约为34.3%,当2种疾病同时存在时血清特异性IgE显著升高,AR对慢性鼻-鼻窦炎鼻息肉发生、发展有明显影响。Objective：To investigate the correlation of allergic rhinitis and chronic rhinosinusitis with nasal polyps in the Ningxia region.Method：One hundred and sixteen patients diagnosed with allergic rhinitis,chronic rhinosinusitis with nasal polyps,allergic rhinitis combined with chronic rhinosinusitis with nasal polyps in the department of Otorhinolaryngology Head and Neck Surgery,Ningxia Medical University Hospital from 2009 January to December was analysed in this study,followed by grouping the experimental group Ⅰ： allergic rhinitis（AR） group（46 cases）,the experimental group Ⅱ： chronic rhinosinusitis with nasal polyps group（46 cases）,the experimental group Ⅲ： allergic rhinitis combined with chronic rhinosinusitis with nasal polyps group（24 cases）,and the normal control group（31 cases）.The skin prick test was used and the serum specific IgE concentration of selected objects was measured by enzyme linked immunosorbent assay.Result：①The positive rate of specific IgE in the experimental group Ⅰ was 83.3%,the concentrated for specific IgE mainly graded in 0 to 3 level,The total positive rate of specific IgE in the experimental group Ⅱ and Ⅲ were 75.0% and 87.5%.②The specific IgE concentration in the experimental group Ⅰ,Ⅱ,Ⅲ and control group were 10.33±2.12（kU/L）,8.43±2.23（kU/L）,5.28±2.16（kU/L）,1.03±3.96（kU/L）,respectively.The data analyzed using ANOVA showed that the specific IgE concentration in the experimental group Ⅰ,Ⅱ,Ⅲ compared with the control group was significantly different;Conclusion：①The specific IgE concentration in the Ningxia region of allergic rhinitis,chronic rhinosinusitis with nasal polyps were graded in 0 to 3 level,mainly graded in 1 level and lower than other regions The positive rates of the skin prick test about Wormwood,German cockroach,house dust mites and pollen Ⅳ allergen were relatively higher in Ningxia region.② The specific IgE concentration was relatively higher in the allergic rhinitis patients combi

关 键 词：鼻炎 变应性 慢性鼻-鼻窦炎 鼻息肉 皮肤点刺试验 血清特异性IGE 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]