新型醒脑静大鼠鼻腔及静脉注射给药后龙脑的药代动力学研究  

Pharmacokinetics of borneol of new Xing Nao Jing in rats after intranasal and intravenous administration

作　　者：宋逍[1,2] 陆洋[1] 杜守颖[1] 温然[1] 赵雪娇[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]陕西中医学院药学院,咸阳712046

出　　处：《中国新药杂志》2012年第21期2485-2488,共4页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-008);国家自然科学基金面上项目(81073057);教育部博士点基金(20090013110007)

摘　　要：目的:研究新型醒脑静中艾片有效成分龙脑在大鼠鼻腔给药和静注给药后的药代动力学。方法:醒脑静静注给药剂量为12 mg.kg-1,鼻腔给药剂量为150 mg.kg-1。采用气相色谱法测定血中龙脑的浓度,以Kinetica 4.4软件计算药代动力学参数。结果:鼻腔给药醒脑静滴鼻液后,艾片有效成分龙脑能迅速进入血液中,生物利用度可达83%。结论:鼻腔给药后龙脑能迅速而较完全地吸收进入体循环。Objective：To investigate the pharmacokinetics of borneol of new Xing Nao Jing in rat plasma after intravenous（i.v.） and intranasal（i.n.） administration.Methods：Borneol was administered via i.v.at a dose of 12 mg·kg^-1 and i.n.at a dose of 150 mg·kg^-1,respectively.Blood was collected at predetermined intervals for the measurement of borneol concentrations by gas chromatography.The calculations of pharmacokinetic parameters were performed by compartmental analysis using Kinetica 4.4 software.Results：Borneol rapidly entered plasma after intranasal administration.The intranasal bioavailability was 83%.Conclusion：Borneol can be absorbed into the systemic circulation rapidly and completely after intranasal administration.Intranasal administration may be a promising alternative to intravenous administration for borneol.

关 键 词：醒脑静 药代动力学 鼻腔给药 静注给药 龙脑 

分 类 号：R969.1[医药卫生—药理学]