甘草酸药理作用的研究进展  

Recent research progress in pharmacological effects of glycyrrhizic acid

作　　者：韩瑶聃[1] 王彬 王政雨[1] 张亚弢[1] 杨凌云[1] 周金培[1] 张惠斌[1] 

机构地区：[1]中国药科大学新药研究中心,南京210009 [2]江苏亚邦药业集团技术中心,常州213200

出　　处：《中国新药杂志》2012年第21期2499-2505,共7页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(130973638);江苏省产学研联合创新资金-前瞻性联合研究项目(BY2011158)

摘　　要：甘草的使用已有几千年历史,现在在世界各地广泛应用。甘草酸是中药甘草根部提取物中的重要成分之一,含有2分子葡萄糖醛酸和1分子甘草次酸,具有水溶性。甘草酸在临床上得到了广泛应用,甚至食品中也有使用。甘草酸有多种生物活性,例如抗炎、抗溃疡、抗过敏、抗氧化、免疫调节、抗病毒、抗癌和保肝等。此外与其他药物联用,甘草酸可起增效作用。本文综述了甘草酸的药理作用。Glycyrrhizic acid,the main water-soluble constituent extracted from the roots of the Chinese herb Glycyrrhiza glabra,has been used for several thousands of year in traditional Chinese medicine.Both glycyrrhizic acid and its aglycone glycyrrhtic acid（GA） have been proven to be useful for various therapeutic purposes.Glycyrrhizic acid is used as a flavoring agent in some candies,pharmaceuticals,and tobacco products and is known for its anti-inflammatory,anti-ulcer,anti-allergic,anti-oxidant,immunomodulatory,anti-viral,anti-tumor and liver-protecting activities.In addition,glycyrrhizic acid has synergistic effect with other drugs.This paper reviewed the recent research progress in pharmacological effects of glycyrrhizic acid.

关 键 词：甘草酸 药理作用 抗炎 研究近况 

分 类 号：R961.1[医药卫生—药理学]