国产紫杉醇致急性中枢神经系统毒性1例  

One case of acute central nervous system toxicity after infusion of home-produced paclitaxel in China

作　　者：何东宁[1] 王艳丽[1] 哈敏文[1] 

机构地区：[1]辽宁医学院第一附属医院肿瘤科,锦州121001

出　　处：《中国新药杂志》2012年第21期2581-2582,共2页Chinese Journal of New Drugs

摘　　要：1例无法手术的老年男性小细胞肺癌患者,经2周期EP(依托泊苷+顺铂)方案化疗后病情进展,接受国产紫杉醇化疗,100 min后出现急性中枢神经系统毒性,具体表现为双手指端发麻、四肢颤抖、牙关颤抖及呻吟、问答合理但不可控制地重复答案。上述症状反复发作约8次,持续共4 h后完全缓解,无其他并发症发生。紫杉醇可导致急性一过性的中枢神经系统毒性,且与紫杉醇剂量无关,停药后可自行缓解。An old male patient with inoperable small cell lung cancer,who had progressive disease after two cycles of chemotherapy with EP regimen,developed acute central nervous system toxicity after 100 min of infusion of domestic paclitaxel injection,with symptoms including numbness of finger tips,limbs trembling,jaw trembling and moaning.He answered question reasonably,but repeated the answers uncontrollably.All the symptoms attacked recurrently for about eight times and resolved completely after 4 hours with no complication.From this we can conclude that paclitaxel can cause acute transient central nervous system toxicity,which is irrelevant with the dose of paclitaxel and resolves spontaneously after withdraw of paclitaxel.

关 键 词：紫杉醇 中枢神经系统毒性 不良反应 脑病 化学治疗 

分 类 号：R979.1[医药卫生—药品] R969.3[医药卫生—药学]