替卡西林钠的合成新工艺  

New process for the synthesis of ticarcillin disodium salt

作　　者：郭剑虹 周改平 李祖文 

机构地区：[1]山西博康药业有限公司,山西太原030021

出　　处：《临床医药实践》2012年第11期841-843,共3页Proceeding of Clinical Medicine

摘　　要：目的:制备替卡西林钠。方法:以3-噻吩丙二酸为起始原料,经过酰氯化、酰胺化、成盐反应制得替卡西林单钠。替卡西林单钠与碳酸氢钠在水溶液中反应后,真空冷冻干燥制得替卡西林钠。结果:总收率62.8%,含量>98.0%。结论:该方法制备的替卡西林钠收率高,质量好,易于实现工业化。Objective：To prepare ticarcillin disodium salt.Methods：The objective compound was synthesized from ticarcillin sodium by salted with sodium bicarbonate and then through freeze-drying.Ticarcillin sodium was prepared from 3-thiophene malonic acid by acylchloride,amidation and salted with 2-ethylhexanoate sodium.Results：Qverall yield was 62.8% and assay was exceeding 98.0%.Conclusion：Ticarcillin disodium salt prepared by this method which was obtained with high yield and good quality.In addition this method was suitable for commercial production scales.

关 键 词：替卡西林 化学合成 3-噻吩丙二酸 抗生素 

分 类 号：R465.1[医药卫生—临床医学]