解磷注射液对急性重度有机磷农药中毒中间综合征预防效果的临床研究  

The clinical study on the JieLin injection's prevention effect of intermediate syndrome caused by acute severe organophosphorus pesticide poisoning

作　　者：袁阳[1] 谢顺成[1] 王俊[1] 

机构地区：[1]四川省遂宁市第一人民医院,629000

出　　处：《临床合理用药杂志》2012年第32期14-15,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的对比解磷注射液与解磷定联合阿托品对急性重度有机磷农药中毒(ASOPP)中间综合征(IMS)的预防效果。方法将ASOPP患者223例随机分为A组86和B组117例。A组予以解磷注射液治疗,B组予以解磷定联合阿托品治疗。比较2组治疗后IMS发生率。结果 A组治疗后IMS发生率为6.98%,低于B组的14.53%,差异有统计学意义(P<0.05)。结论 ASOPP急性期及早、足量、重复应用解磷注射液可有效降低IMS的发生。Objective To compare the prevention effect of Jielin injection, pralidoxime combined with atropine on in- termediate syndrome （IMS） caused by acute severe organophosphorus pesticide poisoning （ASOPP）. Methods 203 cases of patients with ASOPP were randomly divided into group A （86 eases） and group B （ 117 cases）. The group A was treated with Jielin injection,while group B was treated with pralidoxime and atropine. The incidence rate of IMS of 2 groups was compared after treatment. Results The IMS incidence rate of group A was 6.98% ,which was lower than 14.53% of the group B,and the difference was statistically significant （ P 〈 O. 05 ）. Conclusion During the acute phase of ASOPP, the early, adequate and repeated application of Jielin injection can reduce the occurrence of intermediate syndrome effectively.

关 键 词：解磷注射液 解磷定 阿托品 中毒 有机磷农药 急性 中间综合征 

分 类 号：R595.4[医药卫生—内科学]