创伤性颅脑损伤标志物的研究进展  

Research Progress of Markers of Traumatic Brain Injury

作　　者：叶继业[1] 刘绍明[2] 

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]兰州军区乌鲁木齐总医院神经外科,乌鲁木齐830000

出　　处：《医学综述》2012年第20期3350-3352,共3页Medical Recapitulate

摘　　要：创伤性颅脑损伤(TBI)严重危害人类的生活和健康,在众多创伤性疾病中最易引起患者残疾和死亡。如何客观、快速、准确、早期对TBI做出诊断和严重程度分级,对TBI的临床治疗和预后起着重要作用。颅脑损伤标志物在损伤早期就可出现在血清和脑脊液中,其敏感性和特异性往往比影像学检查更具优势。现就常见的TBI标志物研究现状和实际应用情况予以综述。Traumatic brain injury（TBI）causes great damage to people′s life and health,and it could most likely lead to disability and death in many traumatic diseases.How to make a quick,accurate and objective diagnosis in the early stage is quite important for the clinical treatment and prognosis.Biomedical markers of TBI appear early in the serum and cerebro-spinal fluid with a higher sensitivity and specificity than image examination.Here is to make a brief review on the commonly seen TBI markers based on the current studies and applications.

关 键 词：创伤性颅脑损伤 S100Β蛋白 神经元特异性烯醇化酶 神经胶质纤维酸性蛋白 髓磷脂碱性蛋白 TAU蛋白 

分 类 号：R651[医药卫生—外科学]