急性早幼粒细胞白血病合并分化综合征的防治进展  

Prevention and Treatment Progress of Acute Promyelocytic Leukemia Combined with Differentiation Syndrome

作　　者：刘双霞[1] 胡龙虎[1] 

机构地区：[1]哈尔滨医科大学附属第一医院血液内科,哈尔滨150001

出　　处：《医学综述》2012年第20期3450-3453,共4页Medical Recapitulate

摘　　要：急性早幼粒细胞白血病(APL)是急性髓细胞白血病的特殊类型,以t(15;17)为特征。由于蒽环类药物、全反式维甲酸及亚砷酸的应用,使APL的完全缓解率高达90%,5年无病生存率可达85%,使APL成为可以治愈的疾病。但诱导缓解治疗期间出现的分化综合征是严重的并发症,可导致早期死亡,会降低APL的完全缓解率和总体生存率。现对分化综合征的发病机制、诊断、高危因素及防治进展予以简要综述。Acute promyelocytic leukemia（APL）is a special type of acute myeloid leukemia featured with t（15;17）.As a result of anthracycline,all-trans retinoic acid（ATRA）and Arsenious Acid（ATO）application,APL complete remission rate was as high as 90%,5 years of disease-free survival rate was up to 85%,wich makes APL a curable disease.But during remission induction,differentiation syndrome is a serious complication,which can lead to earty stage death,may reduce APL CR rate and the overall survival rate.Here is to make a brief overview on the pathogenesis,diagnosis,risk factors,prevention and cure of differentiation syndrome.

关 键 词：分化综合征 急性早幼粒细胞白血病 发病机制 治疗 

分 类 号：R552[医药卫生—血液循环系统疾病]