激素治疗对特发性肺间质纤维化患者血清MMP-2和TIMP-1及Ⅳ型胶原水平的影响  

The effect of hormone in treating idiopathic pulmonary interstitial fibrosis on the levels of MMP-2,TIMP-1 and type Ⅳ collagen

作　　者：李繁丽[1] 戈艳蕾[2] 刘聪辉[1] 王红阳[2] 

机构地区：[1]河北联合大学附属医院急诊科,河北省唐山市063000 [2]河北联合大学附属医院呼吸内科,河北省唐山市063000

出　　处：《河北医药》2012年第17期2572-2573,共2页Hebei Medical Journal

摘　　要：目的观察特发性肺间质纤维化(IPF)患者血清基质金属蛋白酶-2(MMP-2)、基质金属蛋白抑制因子(TIMP-1)及Ⅳ型胶原(Ⅳ-C)含量及激素治疗前后对其影响。方法选择50例IPF患者及15例健康对照人群,测定IPF患者及对照组血清MMP-2、TIMP-1及Ⅳ-C水平;IPF患者予口服激素治疗,据IPF患者治疗后临床症状缓解程度,判定为治疗有效组或无效组,比较2组治疗前后血清MMP-2、TIMP-1及Ⅳ-C水平变化。结果 IPF患者治疗前血清MMP-2、TIMP-1及Ⅳ-C含量高于对照组(P<0.05);有效组治疗前血清MMP-2、MMP-2/TIMP-1高于无效组,血清TIMP-1及Ⅳ-C水平低于无效组(P<0.05);有效组治疗后血清MMP-2较治疗前及无效组下降,血清TIMP-1及Ⅳ型胶原治疗前后变化差异无统计学意义(P>0.05),无效组血清MMP-2、TIMP-1及Ⅳ-C水平治疗前后变化差异无统计学意义(P>0.05)。结论治疗前血清MMP-2高可以提示对激素治疗反映较好,血清TIMP-1及Ⅳ-C高,提示激素治疗疗效较差。Objective To investigate the effect of hormone therapy on the serum levels of matrix matalloproteinase-2（MMP-2）,tissue inhibitor of metalloproteinase-1（TIMP-1） and type Ⅳ collagen in patients with idiopathic pulmonary interstitial fibrosis（IPF）.Methods The 50 patients with IPF and 15 healthy subjects（control group） were enrolled in the study,and the serum levels of MMP-2,TIMP-1 and type Ⅳ collagen were detected for all the patients and healthy subjects.The patients were treated by oral hormones,then the patients were divided into efficiency group and no efficiency group according to the relief extent of clinical symptoms,and the changes of serum levels of MMP-2,TIMP-1 and type Ⅳ collagen before and after treatment were detected and compared.Results Before treatment the serum levels of MMP-2,TIMP-1 and type Ⅳ collagen in patients with IPF were significantly higher than those of healthy subjects（P0.05）.Before treatment the serum levels of MMP-2 and the ratio of MMP-2/TIMP-1 in efficiency group were higher than those of no efficiency group,however,the serum levels of TIMP-1 and type Ⅳ collagen in efficiency group were significantly lower than those of no efficiency group（P0.05）;after treatment the serum levels of MMP-2 in efficiency group were decreased,as compared with those before treatment and with those in no efficiency group,but there were no significant differences in the serum levels of TIMP-1 and type Ⅳ collagen before treatment and after treatment（P0.05）,nor were the serum levels of MMP-2,TIMP-1 and type Ⅳ collagen before treatment and after treatment in no efficiency group（P0.05）.Conclusion The higher levels of serum MMP-2 in patients with IPF may suggest that the therapeutic effect of hormone is better,however,the the higher levels of serum TIMP-1 and type Ⅳ collagen may suggest that the therapeutic effect of hormone is worse.

关 键 词：特发性肺间质纤维化 基质金属蛋白酶 金属蛋白酶抑制因子 Ⅳ型胶原 

分 类 号：R563[医药卫生—呼吸系统]