茵陈蒿汤不同提取物对黄疸模型小鼠的药效比较  

Potency Comparation of Different Extracts from Yinchenhao Decoction on the Mice Jaundice Model

作　　者：安莉萍[1] 窦志华[2] 罗琳[3] 陈敏[2] 杨爱华[1] 

机构地区：[1]南京中医药大学药学院,210046 [2]南通大学附属南通第三医院药剂科,226006 [3]南通大学医学院药理教研室,226001

出　　处：《医药导报》2012年第11期1407-1409,共3页Herald of Medicine

基　　金：江苏省高校自然科学基础研究项目(08KJB360009);江苏省中医药局中医药科学技术研究专项课题(HZ07071)

摘　　要：目的筛选茵陈蒿汤保肝退黄的药效部位。方法采用α-萘异硫氰酸酯(ANIT)制备小鼠黄疸模型,分别灌胃给予低、中、高剂量茵陈蒿汤75%乙醇提取物及其药渣水提取物,观察小鼠血清总胆红素(T-BiL)、碱性磷酸酶(ALP)、丙氨酸氨基转移酶(ALT)、总胆汁酸(TBA)及胆汁分泌量。结果与模型组比较,醇提部位低剂量组T-BiL、ALP、ALT、TBA及水提部位高剂量组T-BiL、ALP、ALT显著下降(P<0.01或P<0.05);醇提部位低、中剂量组及水提部位高剂量组胆汁分泌量明显增加(P<0.05)。结论茵陈蒿汤醇提部位及醇提后的水提部位具有一定保肝退黄作用。Objective To screen the liver protection and jaundice elimination fraction of yinchenhao decoction（YCHD）.Methods The mice jaundice model was induced by i.g.alpha-naphthylisothiocyanate（ANIT）.The total bilirubin（T-BiL）,alkaline phosphatase（ALP）,alanine aminotransferase（ALT） and total bile acid（TBA） in the serum were determined after intragastric administration of low,middle,and high dose of 75% ethanol extract of YCHD（EE） and water extract of the residue of YCHD extracted by ethanol（WE）,respectively.And the bile secretion of mice was determined as well.Results Compared with the model group,T-BiL,ALP,ALT and TBA of low dose EE group and T-BiL,ALP,ALT of high dose WE group decreased significantly（P0.01 or P0.05）.In addition,bile secretion of the low and middle EE groups,high dose WE group increased significantly（P0.05）.Conclusion Both EE and WE of YCHD decoction possess the liver protection and jaundice retreating effect on ANIT-induced jaundice model of mice.

关 键 词：茵陈蒿汤 黄疸 保肝退黄 药效 

分 类 号：R286[医药卫生—中药学] R965[医药卫生—中医学]