心肌梗死患者血清HIF-1α、VEGF的表达与心肌缺血显像的相关性  

Expressions of serum HIF-1α and VEGF and the correlation between the expression and the myocardial ischemia imaging

作　　者：贺永明[1] 章斌[2] 杨向军[1] 吴翼伟[2] 

机构地区：[1]苏州大学附属第一医院心内科,江苏苏州215006 [2]苏州大学附属第一医院核医学科,江苏苏州215006

出　　处：《苏州大学学报（医学版）》2012年第5期692-695,共4页Suzhou University Journal of Medical Science

基　　金：江苏省第4期"333高层次人才培养工程"资助项目[2011(III)-2663];苏州市科技计划项目(YJS0910)

摘　　要：目的采用单光子发射型计算机断层(SPECT)显像技术研究缺血存活心肌与缺氧诱导因子-1((HIF-1α)和血管内皮生长因子(VEGF)变化的相关性。方法201Tl再分布显像判断心肌梗死患者缺血存活心肌的多寡;再以ELISA法检测患者HIF-1α和VEGF水平,并分析201Tl显像检测缺血存活心肌与HIF-1α和VEGF的相关性。结果 SPECT显像检测获得的缺血存活心肌总积分与血清HIF-1α、VEGF水平变化显著相关(均P<0.001)。结论缺血存活心肌节段总积分与HIF-1α、VEGF相关,检测血清HIF、VEGF可为指导冠心病介入治疗提供一个简单而实用的方法。Objective To study the correlation between the viable myocardia detected by SPECT technique and serum hypoxia inducible factor-1α（HIF-1α）,vascular endothelial growth factor（VEGF）.Methods Ischemic/viable myocardia after myocardial infarction was detected with the thallium-201 redistribution imaging;HIF-1α and VEGF levels were measured with ELISA.The correlation was analyzed.Results A significant correlation was revealed between the global score of ischemic/viable myocardia obtained from SPECT imaging and the changes of HIF-1α and VEGF（all P0.001）.Conclusion The correlation between the global score and the changes of HIF-1α and VEGF may provide a simple,practicle and alternative method for interventional therapy in patients with coronay artey diseases.

关 键 词：单光子发射型计算机断层 乏氧诱导因子-1Α 血管内皮生长因子 心肌梗死 相关性 

分 类 号：R542.22[医药卫生—心血管疾病]