缺氧诱导因子-2α在子宫颈鳞癌组织中的表达及临床意义  

Expression and clinical significance of HIF-2α in cervical cancer tissues

作　　者：江丽霞[1] 施桥发[2] 施少华[1] 李峰[1] 刘四君[3] 

机构地区：[1]赣南医学院第一附属医院,江西赣州341000 [2]南昌大学,江西南昌330000 [3]赣南医学院,江西赣州341000

出　　处：《检验医学》2012年第10期819-821,共3页Laboratory Medicine

基　　金：国家自然科学基金资助项目(30760280);江西省自然科学基金资助项目(2011ZBAB204019);江西省卫生厅课题资助项目(20072016;20113071);赣南医学院重点课题资助项目(ZD2009005)

摘　　要：目的研究缺氧诱导因子-2α(HIF-2α)在子宫颈鳞癌组织中的表达情况及与肿瘤生物学特征的关系。方法免疫组织化学染色方法检测子宫颈鳞癌组织中HIF-2α的表达。结果 40例子宫颈鳞癌组织中HIF-2α阳性表达得分为4.51±1.04,明显高于15例正常子宫颈组织的得分(2.28±1.60,P<0.001);子宫颈鳞癌患者中,有淋巴结转移的组织得分为5.00±0.89,也明显高于无淋巴结转移组织的得分(4.00±0.83,P<0.01);HIF-2α的阳性表达与子宫颈鳞癌患者的年龄无关,与子宫颈癌组织的FIGO2009分期、肿瘤大小有关。结论HIF-2α的表达与子宫颈鳞癌的生长、侵袭有密切关系。Objective To investigate the relationship between hypoxia inducible factor-2 alpha（HIF-2α） expression and tumor biological characteristics in cervical cancer tissues.Methods The expression of HIF-2α in cervical cancer tissues was detected by immunohistochemistry staining method.Results The score of HIF-2α positive expression in 40 samples of cervical cancer tissues was 4.51±1.04.Compared with the score of 2.28±1.60 for 15 samples of normal cervical tissues,there was statistical significance between them（P0.001）.In 40 samples of cervical cancer tissues,the score of HIF-2α positive expression in the samples with lymph node metastasis（5.00±0.89） was higher than that without lymph node metastasis（4.00±0.83,P0.01）.Although there was no relationship between the age of the patients and HIF-2α positive expression,the relationship of FIGO2009 staging and size of the tumor with HIF-2α positive expression was found.Conclusions The expression of HIF-2α correlates closely with the growth and invasion of cervical cancer.

关 键 词：缺氧诱导因子-2Α 子宫颈鳞癌 免疫组织化学染色 

分 类 号：R446.62[医药卫生—诊断学]