36254例妊娠期孕妇风疹病毒感染状况分析  

Analysis of rubella virus infection among pregnant women in 36 254 cases

作　　者：索庆丽[1] 胡晞江[1] 姚婷[1] 

机构地区：[1]武汉市妇女儿童医疗保健中心生殖医学实验室,430016

出　　处：《重庆医学》2012年第32期3380-3382,共3页Chongqing medicine

摘　　要：目的调查武汉市妇幼保健院10年妊娠期孕妇风疹病毒(RV)感染和易感状况,为预防妊娠期RV感染和胎儿先天性风疹综合征(CRS)提供参考依据。方法用酶联免疫吸附法(ELISA)检测36 254例孕妇血清中RV-IgM和RV-IgG两项指标,将其分为多种感染模式,采用两组或多组比较的χ2检验进行统计分析。结果孕妇RV-IgM阳性率为1.52%,其中,妊娠期RV原发感染孕妇为1.02%;中孕期RV易感率显著高于早孕;早孕期近期未感染RV且对其具有免疫力的孕妇显著高于中、晚孕期的孕妇;孕妇RV易感率随年龄增长有明显增高趋势。结论该院10年妊娠期孕妇RV的近期感染率处于中间水平,育龄妇女和孕妇RV自然感染率较高;各级医疗保健机构应加强早、中孕期RV易感孕妇的管理,指导易感育龄妇女风疹疫苗接种;要做好高龄孕妇预防RV感染的工作。Objective To investigate the rubella virus（RV） infection and susceptibility condition among pregnant women in Wu ban maternal and child health hospital for 10 years,and to provide references for the prevention of pregnancy RV infection and con genital rubella syndrome（CRS）. Methods ELISA was used to measure the RV-IgM and RV-IgG in the serum samples of 36 254 cases of RV infected pregnant women,which were divided into a variety of infection models,and we used two or more group z test for statistical analysis. Results The positive rate of RV-IgM among pregnant women was 1.52 % ,of which the primary RV infec tion during pregnancy was 1.02 % ;the RV susceptibility rate during middle pregnancy was significantly higher than early pregnan cy, recent RV uninfected and immunized pregnant women in early pregnancy were significantly higher than middle and later preg nancy^RV susceptible rate in pregnant women increased significantly with increasing age trend. Conclusion The recent RV infec tion rate of pregnant women in that hospital for 10 years is at an intermediate level. RV natural infection rate was higher among childbearing aged and pregnant women. The health care institutions at all levels should strengthen the management of RV suscepti- ble pregnant women during early and middle pregnancy and guide the susceptible women of childbearing age to accept vaccination and prevent aged pregnant women from RV infection.

关 键 词：孕妇 风疹病毒 感染 

分 类 号：R714.2[医药卫生—妇产科学]