补肾活血方对血管性痴呆大鼠海马的保护作用  

Protective Effect of Bushen Huoxue Prescription on Hippocampus of Rats with Vascular Dementia

作　　者：马占强[1] 葛明[1] 

机构地区：[1]中国人民解放军第91中心医院全军精神疾病防治研究所,河南焦作454003

出　　处：《河南中医》2012年第9期1140-1142,共3页Henan Traditional Chinese Medicine

摘　　要：目的:观察补肾活血方对血管性痴呆大鼠海马的保护作用。方法:选取健康成年雄性Wistar大鼠30只,随机分为假手术组、模型组、补肾活血组,制备大鼠血管性痴呆模型。补肾活血组以补肾活血方按临床成人剂量的7倍给药,即0.5 g/kg,按照大鼠体质量以0.01 mL/g的剂量灌胃给药;假手术组和模型组同时予以蒸馏水灌胃,按照大鼠体质量以0.01 mL/g的剂量灌胃。各组大鼠造模结束第2天开始给药,1次/d,连续处理4周。结果:补肾活血组大鼠海马CA1区锥体细胞排列介于模型组与假手术组之间;补肾活血组大鼠的海马CA1区细胞数与假手术组相比没有显著性差异,但是明显高于模型组大鼠的海马CA1区细胞数。结论:补肾活血方对血管性痴呆大鼠海马CA1区锥体细胞有明显保护作用。Objective： To observe the protective effect of Bushen Huoxue Prescription on hippocampus of rats with vascular dementia. Methods： 30 healthy male Wistar rats were randomly divided into sham operation group, model group, Bushen Huoxue group, the vascular dementia rat models were prepared. Bushen Huoxue group were given Bushen Huoxue prescription according to 7 times of clinical adult dose, namely 0.5 g/kg, according to body mass of rats with 0.01 ml/g dose; sham operation group and model group at the same time were given distilled water according to the body weight of rats 0.01 ml/g dose. Rats in each group were given medicine on the second day of the end of modeling, 1 /d, 4 week of continuous processing. Results： The rat hippocampal CAt pyramidal ceils of Bushen Huoxue group arranged between model group and sham operation group. Rat hippocampal CA1 cells of Bushen Huoxue group had no significant difference compared with those of sham operation group, but the CAI hippoeampal cell numbers were signifieantly higher than those in the rats of model group. Conclusion ： Bushen Huoxue Prescription has obvious protective effeet on hippoeampal CAI pyramidal cell of vascular dementia rat.

关 键 词：补肾活血方 血管性痴呆 海马CA1区锥体细胞 雄性Wistar大鼠 

分 类 号：R285.5[医药卫生—中药学]