Experimental measurement of the correlation between CT number and heavy ion range  

作　　者：贺鹏博 李强 刘新国 叶飞 戴中颖 

机构地区：[1]Institute of Modern Physics, Chinese Academy of Sciences [2]Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences [3]Graduate University of Chinese Academy of Sciences

出　　处：《Chinese Physics C》2012年第10期954-957,共4页中国物理C（英文版）

基　　金：Supported by National Basic Research Program of China (973 Program, 2010CB834203);Key Project of National Natural Science Foundation of China (10835011);National Natural Science Foundation of China (10905080, 11075191);Science and Technology Development Project of Lanzhou City (2008-sr-10, 2009-2-12)

摘　　要：For precision delivery of the Bragg peak of a heavy-ion beam to a target volume in ion beam therapy, it is necessary to know the tissue stopping power. A general approach to solve this problem in ion beam therapy is to convert X-ray CT （computed tomography） numbers into water-equivalent path length （WEPL） coefficients using a CT-WEPL calibration curve for all voxels traversed by the beam. This work aims at establishing a CT-WEPL coefficient calibration curve for the heavy ion therapy project at IMP, so as to compute the range of carbon ion beams in tissues easily according to the patient CT data. Several tissueequivalent materials were applied to measure their WEPL coefficients using a high-energy carbon ion beam in this work. A CT-WEPL calibration curve was obtained through fitting the measured data, which can be used directly for dose optimization and facilitates the design of patient treatment plans significantly at IMP.For precision delivery of the Bragg peak of a heavy-ion beam to a target volume in ion beam therapy, it is necessary to know the tissue stopping power. A general approach to solve this problem in ion beam therapy is to convert X-ray CT （computed tomography） numbers into water-equivalent path length （WEPL） coefficients using a CT-WEPL calibration curve for all voxels traversed by the beam. This work aims at establishing a CT-WEPL coefficient calibration curve for the heavy ion therapy project at IMP, so as to compute the range of carbon ion beams in tissues easily according to the patient CT data. Several tissueequivalent materials were applied to measure their WEPL coefficients using a high-energy carbon ion beam in this work. A CT-WEPL calibration curve was obtained through fitting the measured data, which can be used directly for dose optimization and facilitates the design of patient treatment plans significantly at IMP.

关 键 词：heavy ion therapy CT number WEPL CT-WEPL calibration curve 

分 类 号：O571.6[理学—粒子物理与原子核物理]