组织应变成像评价择期冠状动脉介入治疗改善急性心肌梗死患者左心室功能的作用机制  被引量:1

Tissue Strain Imaging Evaluation of Left Ventricular Function Improvement in Patients with Acute Myocardial Infarction by Elective Percutaneous Coronary Intervention

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作  者:邹麓[1] 贾大林[1] 马春燕[2] 刘爽[2] 张妍[2] 张立敏[2] 

机构地区:[1]中国医科大学附属第一医院心血管内科,沈阳110001 [2]中国医科大学附属第一医院心血管超声科,沈阳110001

出  处:《中国医科大学学报》2012年第11期1037-1040,共4页Journal of China Medical University

基  金:辽宁省教育厅高校科研计划(L2010667)

摘  要:目的应用组织应变成像(SI)评价择期经皮冠状动脉介入治疗术(PCI)对急性ST段抬高型心肌梗死(ASTEMI)患者左心室整体及局部心肌功能的作用及机制。方法收集因首次ASTEMI入院并行择期PCI的患者59例,根据冠状动脉造影及室壁运动状态将心肌分为梗死组(MI组,n=114)、缺血组(ISCHE组,n=97)及对照组(Con组,n=183)。于术前3 d内及术后1个月行常规超声心动图和组织多普勒(TDI)检查。测得常规超声心动图及TDI指标。结果术后1个月,左心室舒张末内径(LVEDD)、收缩末内径(LVESD)及收缩末容积(LVESV)缩小[(55.94±3.81)mm vs(51.72±3.89)mm;(34.28±4.43)mm vs(30.81±3.97)mm;(47.27±10.88)mL vs(43.75±10.82)mL,P<0.05];射血分数(LVEF)增加[(55.98±6.32)%vs(58.17±6.64)%,P<0.01];二尖瓣环收缩期峰速度(S′a)增加[(8.57±2.39)cm/s vs(10.93±3.35)cm/s,P<0.05];二尖瓣舒张早期血流速度/二尖瓣环舒张期峰速度(E/E′a)减小[(6.91±1.06)vs(5.52±1.18),P<0.01];ISCHE组心肌应变(S)增加[(12.81±4.23)%vs(14.96±4.60)%,P<0.05],但MI组无变化[(11.16±5.10)%vs(12.72±4.98)%,P>0.05]。结论择期PCI能够改善ASTEMI患者缺血心肌功能,组织应变可准确评价心肌局部功能。Objective To investigate the left ventricular (LV) global and segmental function change and the mechanism in acute ST ele- vation myocardial infarction (ASTEMI) patients after elective percutaneous coronary intervention (PCI) using strain imaging (SI). Methods Fifty-nine consecutive patients admitted with first-time ASTEMI and underwent elective PCI within seven to ten days were recruited. Tissue Doppler imaging (TDI) parameters were determined three days before and one month after elective PCI. All myocardial segments were subdivided into myocardial infarction (MI) group (n =114),ischemic (ISCHE) group (n =97) and control (Con) group (n =183) based on coronary angiography and wall motion status. Ultrasonic cardiogram and TDI parameters were determined. Results One month after elective PCI,LV end-diastolic diameter (LVEDD) ,LV end-systolic diameter (LVESD) and LV end-systolic volume (LVESV) decreased (55.94 ± 3.81 mm vs 51.72±3.89 mm;34.28±4.43 mm vs 30.81±3.97 mm;47.27±10.88 mL vs 43.75±10.82 mL;P 〈 0.05);LV ejection fraction (EF) increased (55.98±6.32)% vs (58.17±6.64)%;P 〈 0.01;and systolic peak-velocity of miual annulus (S'a) increased (8.57±2.39 cm/s vs 10.93±3.35 cm/s;P 〈 0.05);transmitral to mitral annular early diastolic velocity ratio(E/E'a) decreased(6.91±1.06 vs 5.52±1.18; P 〈 0.01 ). Strain ( S ) of ISCHE group increased ( 12.81±4.23 % vs 14.96±4.60 % ; P 〈 0.05 ), while no signiticant difference was observed in the MI group (11.16±5.10 % vs 12.72±4.98 %;P〉 0.05). Conclusion Elective PCI application on the ischemic myocardium lead to a better global La function of ASTEMI patients, and regional myocardial function could be accurately determined by SI.

关 键 词:择期冠状动脉介入治疗 急性心肌梗死 组织多普勒成像 应变 

分 类 号:R541.4[医药卫生—心血管疾病]

 

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