辛伐他汀对兔动脉粥样硬化斑块结构及巨噬细胞移动抑制因子的影响  

Study of the plaques characterization and the expression of MIF during atherosclerosis in rabbits with the intervention of simvastin

作　　者：周程[1] 刘福林[1] 李鹤飞[1] 李亚琴[1] 周晓东[1] 徐占稳[1] 

机构地区：[1]河北大学附属医院心脏科,河北省保定市071000

出　　处：《实用医学杂志》2012年第22期3703-3705,共3页The Journal of Practical Medicine

基　　金：河北省2010年医学科学研究重点课题计划(编号:20100142)

摘　　要：目的:通过研究辛伐他汀干预治疗兔动脉粥样硬化过程中,斑块组成结构及兔血清中巨噬细胞移动抑制因子(MIF)水平及其二者的相关性,探讨MIF在动脉粥样硬化过程中的意义及辛伐他汀的作用。方法:研究对象为新西兰大白兔,随机分为正常对照组,腹主动脉球囊拉伤、高脂饲养构建的兔动脉粥样硬化模型组,辛伐他汀干预动脉粥样硬化治疗组;观测各组实验对象腹主动脉斑块纤维帽厚度,并获得纤维帽的厚度与脂核横截面厚度的比值;采用ELISA法检测其血清巨噬细胞移动抑制因子水平。结果:动脉粥样硬化模型组斑块纤维帽较薄,脂核相对较大,他汀干预治疗组斑块纤维帽厚度明显高于动脉粥样硬化模型组,而脂核厚度则相对较小;动脉粥样硬化模型组MIF水平较对照组升高,干预治疗组MIF水平较模型组低,其差异有统计学意义(P<0.05)。结论:辛伐他汀干预可以改变斑块的组成结构,降低MIF水平,使动脉粥样硬化斑块更加趋于稳定。Objective To study the effects of simvastin on atherosclerosis rabbits by analyzing the characterization of atherosclerotic plaquein and the levels of MIF （macrophage migration inhibitory factor）. Methods New Zealand rabbits were randomly divided into three groups. The rabbits in control group were given basic food, and the rabbits in model group were given aortic endothelium balloon injury and high lipid diet, and simvastin were given to the treatment group. After 10 weeks, the ratio of thickness of fibrous cap and the lipid core areas were obtained by pathological observation and the levels of serum MIF were determined by ELISA. Results The rabbits in model group had the less weak thickness of fibrous cap and the greater areas of lipid core than the treatment group, and the levels of serum MIF were higher than control group and treatment group. Conclusion Simvastin can make the atherosclerotic plaques more stable by changing the characterization of plaques and the level of MIF.

关 键 词：动脉粥样硬化 巨噬细胞移动抑制因子 易损斑块 辛伐他汀 

分 类 号：R543.5[医药卫生—心血管疾病]