体外循环回路对预充液舒芬太尼浓度的影响  

Effect of extracorporeai circuit on the concentration of sufentanil the priming solution

作　　者：李芳[1] 邸永辉[2] 高金贵[3] 闫世伟 

机构地区：[1]邢台市眼科医院麻醉科,054001 [2]邢台市人民医院胸外科 [3]河北医科大学第二医院麻醉科 [4]邢台市第一医院麻醉科

出　　处：《中华麻醉学杂志》2012年第9期1085-1087,共3页Chinese Journal of Anesthesiology

基　　金：河北省科技计划项目（11276188）

摘　　要：目的评价体外循环回路对预充液舒芬太尼浓度的影响。方法实验分为2组（n=6）：西京90型大号鼓泡式氧合器体外循环回路组（A组）和玻璃容器组（B组）。将预充液（琥珀酰明胶液1000ml和乳酸钠林格氏液1000m1）预充人大号鼓泡式氧合器体外循环装置或玻璃容器中，从静脉贮血器的静脉端或玻璃容器口快速加入舒芬太尼15μg（浓度为7．5ng／ml）。在加药后3、5、10、20、30、40、50、60、70、80、90min时，从静脉贮血器的动脉端或玻璃容器中抽取预充液1ml，采用气相色谱质谱法检测舒芬太尼浓度。结果与B组比较，A组各时点预充液舒芬太尼浓度明显降低（P〈0．05）。结论体外循环回路对预充液舒芬太尼有明显吸附作用。Objective To investigate the effect of extracorporeal circuit on the concentration of sufentanil the priming solution. Methods The extraeorporeal circuit （ECC） of Xi-jing-90 type （group A） was used in the study , while in control group （group B） a glass container was used. The ECC and glass container were filled with priming solution （sueeinylated Gelatin 1000 ml ＋ lactated Ringer＇s solution 1000 ml）. Sufentanil 15 tag was then added to the priming solution （the final concentration was 7.5 ng/ml）. The priming solution was circulated in the closed ECC or stirred in the glass container. The concentration of sufentanil in the priming solution was determined at 3, 5, 10, 20, 30, 40, 50, 60, 70, 80 and 90 min after addition of sufentanil by gas chromatography. Results The sufentanil concentration in the priming solution decreased in group A at the different time points respectively as compared with group B （ P 〈 0.05）. Conclusion Sufentanil can significantly be absorbed by the extracorporeal circuit.

关 键 词：体外循环 舒芬太尼 

分 类 号：R614[医药卫生—麻醉学]