拉贝洛尔在nano-Fe_3O_4-多壁碳纳米管复合修饰玻碳电极上的电催化氧化及电分析方法  

Electrocatalytic oxidation of labetalol at nano-Fe_3O_4-multi-walled carbon nanotubes modified glassy carbon electrode and its electrochemical determination

作　　者：丁玲[1] 张艳梅[1] 高作宁[1] 犹卫[1] 

机构地区：[1]宁夏大学化学化工学院,银川750021

出　　处：《药物分析杂志》2012年第11期2002-2007,共6页Chinese Journal of Pharmaceutical Analysis

基　　金：宁夏自然科学基金(NZ1147)项目资助

摘　　要：目的:研究拉贝洛尔(labetalol,LBT)在nano-Fe3O4与多壁碳纳米管(Multi-walled carbon nanotubes,MWCNTs)复合修饰玻碳电极(nano-Fe3O4-MWCNTs/GCE)上的电化学行为及电化学动力学性质,建立LBT电化学定量测定方法。方法:循环伏安法(Cyclic Voltammetry,CV),计时电流法(Chronoamperometry,CA),方波伏安法(Square Wave Voltammetry,SWV)以及电化学交流阻抗谱(EIS)。结果:在nano-Fe3O4-MWCNTs/GCE上LBT发生了一受扩散控制的不可逆电化学氧化过程。考查了实验条件对LBT伏安行为的影响,测定了LBT在nano-Fe3O4-MWCNTs/GCE上的电极反应过程动力学参数。用SWV法测得LBT氧化峰电流与其浓度在1.0#10-5$1.0#10-3mol.L-1呈线性关系,检出限(S/N=3)为1.0#10-5mol.L-1。并用本方法对市售LBT片进行了电化学定量测定,RSD在0.4%～0.9%之间,加标回收率在99.70%～103.0%之间。结论:nano-Fe3O4-MWCNTs/GCE对LBT电化学氧化具有良好的催化作用,该方法可用于市售LBT片中LBT含量的电化学定量测定。Objective： To study the electrochemical behaviors and electrochemical kinetics of labetalol （LBT）at nano - Fe3O4 - multi - wall carbon nanotubes modified glassy carbon electrode （ nano - Fe3O4 - MWCNTs/GCE ） , so as to establish an LBT electrochemical quantitative assay. Methods：Cyclic voltammetry（ CV）, Chronoamperome- try （ CA ）, Square wave vohammetry （ SWV ） and electrochemical impedance spectrum （ EIS ） were applied. Results： Electrochemical experimental results showed that LBT electrochemical behavior in 0. 10 mol L-1 PBS exhibited an irreversible electrochemical oxidation process at nano - Fe3O4 - MWCNTs/GCE. The influence of the experimental conditions on the vohammetric behaviors of LBT was also examined, and the kinetic parameters of the electrode re- action process were determined. The relationship between LBT oxidation peak current and its concentration was e- valuated by square wave voltammetry （SWV）. The experimental results showed a good linear relationship between the oxidation peak currents of LBT and its concentration in the range of 1.0 ×10-5～1.0×10-3mol·L-1. The de- tection limit was 1.0 ×10-5mol·L-1. The quantitative determination of LBT content was investigated,the relative standard deviation is between 0. 4% - 0. 9% and the recovery rate is in the range of 99.70% - 103.0%. Conclusion：The experimental results indicated that nano -Fe3O4 -MWCNTs/GCE could be a good catalyst for the oxida- tion of LBT. Furthermore, this method can be applied in the determination of commercial LBT content with simple manipulation.

关 键 词：电分析方法 电催化氧化 修饰电极 降压药拉贝洛尔 NANO-FE3O4 多壁碳纳米管 

分 类 号：R917[医药卫生—药物分析学]