川崎病再发22例  

Clinical Analysis of Recurrent Kawasaki Disease in 22 Children

作　　者：孙东明[1] 邓淑珍[1] 王瑞耕[1] 刘玲[1] 夏琨[1] 彭静[1] 

机构地区：[1]武汉市儿童医院心内科,武汉430016

出　　处：《实用儿科临床杂志》2012年第21期1668-1669,1690,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨川崎病(KD)再发的临床特点及其与冠状动脉病变(CAL)的关系。方法回顾性分析本院2003年1月-2010年12月收治的22例再发KD患儿临床资料,并与其初发时的临床资料进行比较分析。并采用SPSS 11.0软件对组间比较进行统计分析。结果再发病例热程较其初发时短,差异有统计学意义[(8.0±2.3)d vs(10.1±3.1)d,P<0.05],但WBC、Hb、PLT、CRP、ESR、FIB水平与初发时比较,差异均无统计学意义(Pa>0.05)。再发病例CAL发生率较初发时增加不显著(P>0.05)。再发病例应用IVIG时间较初发时早[(6.5±1.3)d vs(8.4±2.9)d,P<0.01],而应用后退热时间与初发时比较差异无统计学意义(P>0.05)。结论 KD再发病例临床表现与初发相似,CAL发生率无显著增高,但热程较短,可能与对再发病例认识早、治疗及时有关。Objective To investigate the clinical features of recurrent Kawasaki disease（KD） and the relationship between recurrent KD and coronary artery lesions（CAL）. Methods The clinical data of 22 children with recurrent KD hospitalized in Wuhan Children′s Hospital from Jan.2003 to Dec.2010 were retrospectively studied and compared with their initial onset.The data were analyzed by SPSS 11.0 software. Results Compared with the initial KD group,the total fever duration was remarkably shorter in the recurrent KD group [（8.0±2.3） d vs（10.1±3.1） d,P〈0.05].There was no significant difference in the levels of white blood cell count,platelets,hemoglobin,C-reactive protein,erythrocyte sedimentation rate,fibrinogen and the incidence of CAL between the 2 groups（Pa0.05）.The recurrent KD group received intravenous immunoglobulin（IVIG） earlier than the initial KD group [（6.5±1.3） d vs（8.4±2.9） d,P〈0.01],but the defervescence time after IVIG treatment had no significant difference between the 2 groups（P〉0.05）. Conclusions The clinical manifestations of recurrent KD are similar to initial KD.Recurrent KD may be not associated with an increased incidence of CAL.The total fever duration of recurrent KD is remarkably shorter,which may due to early recognition and timely treatment.

关 键 词：川崎病 再发 冠状动脉病变 

分 类 号：R725.4[医药卫生—儿科]