艾司西酞普兰和氟西汀治疗焦虑抑郁共病的疗效观察  

Control Study of Escitalopram vs Fluoxetine in Treatment of Comorbid Anxiety and Depression

作　　者：韩学青[1] 牛雅娟[2] 张燕波[1] 

机构地区：[1]首都医科大学附属北京同仁医院(北京),中国100730 [2]北京回龙观医院

出　　处：《中国健康心理学杂志》2012年第10期1470-1471,共2页China Journal of Health Psychology

摘　　要：目的比较艾司西酞普兰和氟西汀治疗焦虑抑郁共病的疗效和安全性。方法将61例焦虑抑郁共病患者随机分为艾司西酞普兰组(31例)和氟西汀组(30例),进行开放式临床对照研究,疗程均为6周,采用汉密尔顿抑郁量表(HAMD17)和汉密尔顿焦虑量表(HAMA)评价疗效,采用药物副反应量表(TESS)评价不良反应。结果艾司西酞普兰组临床总有效率为86.6%,氟西汀组为83.3%,差异无统计学意义(χ2=0.131,P>0.05)。治疗1周时,艾司西酞普兰组汉密尔顿抑郁量表和汉密尔顿焦虑量表评分较氟西汀组明显降低(P<0.01),差异有显著性。艾司西酞普兰组未见明显药物不良反应;氟西汀组出现4例药物副反应。结论艾司西酞普兰治疗焦虑抑郁共病患者较氟西汀起效快,药物副反应小。Objective To evaluate the efficacy and safety of Escitalopram vs Fluoxetine in treatment of comorbid anxiety and depression.Methods A total of 66 patients were randomly divided into escitalopram group and fluoxetine group for 6 weeks.The efficacy were evaluated with Hamilton depression rating scale（HAMD）and Hamilton anxiety rating scale（HAMA）,the side effects were evaluated with treatment emergent symptom scale（TESS）.Results The effective rate of the escitalopram group was 86.6%.The effective rate of the fluoxetine group was 83.3%.there was no difference between the two groups in efficacy.After 1 week of treatment,escitalopram group in Hamilton Depression Rating Scale and Hamilton Anxiety Scale scored significantly lower than the fluoxetine group,P0.01.Escitalopram group had no significant adverse drug reactions;fluoxetine group had four cases of adverse drug reactions.Conclusion Escitalopram in the treatment of patients with anxiety and depression has more rapid onset than fluoxetine,and smaller side effects.

关 键 词：艾司西酞普兰 氟西汀 焦虑抑郁共病 汉密尔顿抑郁量表 

分 类 号：R971.43[医药卫生—药品]