霉酚酸酯联合泼尼松治疗难治性肾病综合征合并2型糖尿病  

The treatment of refractory nephrosis syndrome with T2DM using mycophenolate mofetil combined with prednisone

作　　者：尤建立[1] 陈凯[1] 刘宇[1] 

机构地区：[1]河南省开封市第二人民医院内五科,河南开封475002

出　　处：《中国当代医药》2012年第31期73-74,共2页China Modern Medicine

摘　　要：目的探讨霉酚酸酯联合泼尼松治疗难治性肾病综合征合并2型糖尿病的疗效。方法将66例合并2型糖尿病难治性肾病综合征患者随机分为A、B两组,各33例,A组给予霉酚酸酯联合小剂量泼尼松治疗,B组给予泼尼松联合环磷酰胺冲击治疗。两组均给予胰岛素联合吡格列酮(卡司平)控制血糖。结果 A组患者中17例完全缓解,10例部分缓解,总有效率为81.8%。B组10例完全缓解,10例部分缓解,总有效率为60.6%。A组总有效率明显高于B组,且两组均无严重不良反应。结论霉酚酸酯联合泼尼松治疗合并2型糖尿病难治性肾病综合征优于泼尼松联合环磷酰胺冲击治疗,且副作用明显减少。Objective To explore the clinical treatment efficacy of refractory nephrosis syndrome with T2DM using my- cophenolate mofetil combined with prednisone. Methods Sixty-six patients of nephrosis syndrome combined with T2DM were divided into two groups randomly： A and B, and each group had 33 cases. Group A were given mycophenolate mofetil and small dose prednisone. The therapy of group B were prednisone joint with cyclophosphamide. Both groups were used insulin and pioglitazone to control blood glucose. Results Seventeen cases of group A were relieved completely, and 10 cases were relieved un-completely, the total effective rate was 81.8%. Ten cases were relieved completely in group B, and the other 10 cases were relieved partially with the total effect effective rate was 60.6%. Group A was significantly higher than group B, and both group had no serious adverse reaction. Conclusion The treatment of mycophenolate mofetil com- bined with prednisone has more efficacy comparing with prednisone and cyclophosphamide, and the adverse reaction is ob- viously reduced.

关 键 词：霉酚酸酯 难治性肾病综合征 2型糖尿病 疗效 

分 类 号：R692.3[医药卫生—泌尿科学]