NT-proBNP对左室收缩及舒张功能障碍的预测价值  

Predictive value of NT-proBNP on left ventricular contraction and diastolic dysfunction

作　　者：许哲通[1] 冯志霞[1] 王茜[1] 文海燕[1] 

机构地区：[1]河北省保定市第二中心医院,河北涿州072750

出　　处：《中国当代医药》2012年第26期13-15,共3页China Modern Medicine

摘　　要：目的探讨在有心肌收缩及舒张功能障碍的患者中,评估超声心动图参数与血浆NT-proBNP水平的关系。方法该项研究包括96例心力衰竭患者。他们同时接受超声心动图及NT-proBNP检测。结果发现NT-proBNP水平与以下几个超声心动图参数之间有显著相关性,二尖瓣环舒张晚期速度(Am)(r=-0.747,P=0.000),二尖瓣环收缩期运动峰值速度(Sm)(r=-0.731,P=0.000),二尖瓣环舒张早期运动速度(Em)(r=-0.508,P=0.000),二尖瓣口舒张早期血流速度与二尖瓣环舒张早期运动速度之比(E/Em)(r=0.532,P=0.000),左室射血分数(LVEF)(r=-0.819,P=0.000)。多元回归分析显示,logNT-proBNP水平与年龄、左室射血分数、二尖瓣环舒张晚期速度及二尖瓣环舒张早期运动速度独立相关(R2=0.78,P=0.0001),与左室射血分数的相关性最强(β=-0.55)。结论 NT-proBNP水平与超声心动图参数具有相关性,并且是收缩性及舒张性心力衰竭简单而精确的标志物。Objective To explore the correlation between echocardiographic parameters and plasma N-terminal pro brain natriuretic peptide （NT-proBNP） level in patient with systolic or diastolic dysfunction. Methods The study included 96 heart failure patients. They underwent conventional and tissue Doppler imaging （TDI） echocardiography and NT-proBNP level was measured at the same time. Results Significant correlations were found between NT-proBNP level and late diastolic mitral annulus velocity （Am） （r = -0.747, P = 0.000）, systolic mitral annulus velocity （Sm） （r = -0.731, P = 0.000）, early diastolic mitral annulus velocity （Em） （r = -0.508, P = 0.000）, early transmitral to Em velocity ratio （r = 0.532, P = 0.000）, LV ejection fraction （r = -0.819, P = 0.000）. In multiple regression, log NT-proBNP levels were independently related to age, LV ejection fraction, Am velocity and Em velocity （R2 = 0.78, P = 0.000 1）, the relation to ejection fraction was the strongest （β = -0.55）. Conclusion NT-proBNP levels correlate with echocardiographic parameters, and are simple, accurate markers of systolic and diastolic heart failure.

关 键 词：慢性心力衰竭 常规超声心动图 组织多普勒显像 NT-PROBNP 

分 类 号：R54[医药卫生—心血管疾病]