瑞替普酶与阿替普酶在急性肺栓塞溶栓治疗中的比较研究  

COMPARATIVE STUDY OF THROMBOLYTIC THERAPY IN ACUTE PULMONARY EMBOLISM PATIENTS TAKING RETEPLASE OR ALTEPLASE

作　　者：金焱[1] 崔四龙[1] 刘东亮[1] 金鹏[1] 胡新荣[1] 李凌[1] 林静[1] 

机构地区：[1]河南省漯河市中心医院心内科,462000

出　　处：《中国煤炭工业医学杂志》2012年第11期1668-1670,共3页Chinese Journal of Coal Industry Medicine

摘　　要：目的对比研究瑞替普酶与阿替普酶在肺栓塞溶栓治疗中的临床疗效及安全性。方法 50例符合溶栓治疗的急性肺动脉栓塞患者,26例给予瑞替普酶,24例给予阿替普酶溶栓。分别观察溶栓前及溶栓4h后患者的临床表现、心率、血气分析、3d后螺旋CT肺动脉成像的变化及出血等不良反应,比较二者的溶栓效果。结果应用瑞替普酶对急性肺栓塞溶栓后有较好的疗效,未见严重的不良反应。结论应用瑞替普酶对急性肺动脉栓塞进行溶栓有较好的临床疗效及安全性,等同于阿替普酶。Objective To evaluate the effect and safety of reteplase and alteplase in acute pulmonary embolism（PE） patients. Methods Total 50 acute PE patients, corresponding to thrombolytic therapy, were randomly divided into two groups. 26 patients were gived reteplase,the others were gived alteplase in admission . Clinical manifestation,heart rate, blood gas analysis were observed before hrombolysis and after 4 hours after hrombolysis. Pulmonary artery multi- slice spiral CT scan was selected before hrombolysis and after 3 days after hrombolysis. Effects of thrombolysis were evaluated. Results Better effects could befounded in acute PE patients by using reteplase. No severe side effects were discovered. Conclusion Better effects and safety of reteplase are equal to alteplase in acute PE patients.

关 键 词：肺栓塞 瑞替普酶 溶栓治疗 

分 类 号：R563.5[医药卫生—呼吸系统]