从苯乙腈合成氨酰心胺  

Synthesis of Atenolol from Benzylcyanide

作　　者：韦长梅[1] 

机构地区：[1]淮阴师范学院化学系,江苏淮阴223001

出　　处：《淮海工学院学报（自然科学版）》2000年第2期36-38,共3页Journal of Huaihai Institute of Technology:Natural Sciences Edition

基　　金：江苏省教委自然科学基金资助项目!(98KJD150009)

摘　　要：以苯乙腈为原料 ,经过硝化、水解、还原、重氮化和水解、酯化和氨化制备了对羟基苯乙酰胺 ;然后再与环氧氯丙烷及异丙胺反应 ,合成了降压药物氨酰心胺 ,总收率为 1 2 .0 6%;并用元素分析、IR和 1HNMR谱表征了目标化合物的结构。P hydroxy benzeneacetamide is prepared from benzylcyanide after a series of organic reactions such as nitration, hydrolysis,reduction and so on. Then, the P hydroxy benzeneacetamide is reacted with epichlorohydrin and isoproylamine to obtain atenolol—a drug for the treatment of hypertension. The total yield is 12.06% and its structure is characterized by IR and 1 HNMR.

关 键 词：氨酰心胺 对羟基苯乙酰胺 苯乙腈 合成 高血压 

分 类 号：TQ463.4[化学工程—制药化工] R972.4[医药卫生—药品]