蛇床子素水凝胶栓的研制及含量测定  

Preparation and Content Determination of Osthole Aquogel Suppository

作　　者：高捷[1] 常忆凌[1] 单伟光[2] 

机构地区：[1]浙江医药高等专科学校,浙江宁波315100 [2]浙江工业大学,杭州310014

出　　处：《中国现代应用药学》2012年第11期1006-1009,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的制备蛇床子素水凝胶栓,并建立其含量测定方法。方法用正交设计法筛选得到最佳处方,采用HPLC测定蛇床子素水凝胶栓的含量。结果蛇床子素水凝胶栓剂的最佳处方为:海藻酸钠0.4 g、吐温-80 2.4 g、单硬脂酸甘油酯1.2 g、卡波姆0.4 g。该处方条件下,3批栓剂样品的蛇床子素含量分别为每颗13.23,13.95,13.19 mg。结论该处方设计合理,含量测定方法操作简便、快速准确。OBJECTIVE To preparation of osthole aquogel suppository and to establish its assay method. METHODS The optimal formula was optimized by orthogonal experiment and the content of osthole aquogel suppository was determined by HPLC. RESULTS The optimized formula was as follows： sodium alginate 0.4 g, Tween-80 2.4 g, glycerol monostearate 1.2 g, carbomer 0.4 g. With the optimal formula, the content of osthole in 3 batches of suppositories were 13.23, 13.95, 13.19 rag, respectively. CONCLUSION The design of the formula is reasonable, the method for assaying is simple, fast and accurate.

关 键 词：卡波姆 水凝胶 栓剂 正交设计 含量测定 

分 类 号：R943[医药卫生—药剂学]