妊娠期亚临床甲状腺功能减退左旋甲状腺素替代治疗的评价指标探讨  

Investigation of thyroid function parameters in subclinical hypothyroid women treated with levothyroxine during pregnancy

作　　者：苏恒[1] 任秀莲[1] 玛杉[1] 陈红[1] 薛元明[1] 张云[2] 朱宝生[2] 

机构地区：[1]昆明医学院附属昆华医院,云南省第一人民医院内分泌代谢科,650032 [2]云南省第一人民医院遗传诊断中心

出　　处：《中华内分泌代谢杂志》2012年第11期895-896,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：云南省中青年学术技术带头人后备人才项目（2007PY01-32）

摘　　要：妊娠期亚临床甲状腺功能减退（亚临床甲减）可增加多种妊娠不良结局的风险。本研究采用电化学发光免疫分析法，探讨了妊娠期亚临床甲减左旋甲状腺素（L—T4）替代治疗的评价指标。研究发现，L—T4替代治疗中TT4测定与TSH的一致性较好，似可更好地反映替代治疗效果。Subclinical hypothyroidism during pregnancy is associated with some adverse outcomes during maternal pregnancy. The present study investigated thyroid function parameters measured by electrochemiluminescence （ECL） immunoassays in subclinical hypothyroid women treated with levothyroxine （L-T4 ） during pregnancy. The results showed that in evaluating thyroid function with ECL immunoassays during replacement with L-T4, determination of serum 3T4 appears to have a closer correlation with TSH and may better reflect the efficacy of treatment.

关 键 词：妊娠 亚临床甲状腺功能减退症 治疗 免疫测定 左旋甲状腺素 

分 类 号：R581.2[医药卫生—内分泌]