氧化苦参碱对高果糖饮食诱导大鼠脂肪肝的改善作用及机制研究  

Improvement of high-fructose-feeding-induced fatty liver by oxymatrine intervention REN

作　　者：任路平[1] 胡志娟[2] 宋光耀[1] 陈树春[1] 刘娜[1] 魏立民[1] 

机构地区：[1]河北省人民医院内分泌一科,石家庄050000 [2]河北省人民医院肾内科,石家庄050000

出　　处：《中华内分泌代谢杂志》2012年第11期935-937,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30971391）,河北省科技厅围际合作项目（11396406-D）

摘　　要：观察氧化苦参碱干预对高果糖饮食诱导大鼠胰岛素抵抗和肝脏脂质沉积的影响，并探讨其改善肝脏脂质代谢的分子机制。结果表明高果糖喂养降低大鼠葡萄糖耐量，增加肝脏脂质沉积：而氧化苦参碱可改善大鼠糖耐量和肝脏脂质沉积；高果糖喂养刺激大鼠肝脏脂质合成关键酶蛋白表达，而氧化苦参碱干预显著降低了高果糖喂养诱导的肝脏脂质合成关键酶蛋白表达：高果糖喂养和氧化苦参碱干预对大鼠的线粒体脂肪酸氧化酶类表达无明显影响。The effect of oxymatrine on high-fructose-feeding induced insulin resistance and liver steatosis in rats was observed and the underlying mechanism in improving the hepatic lipid metabolism was explored. The results demonstrated that high fructose feeding decreased the glucose tolerance and increased hepatic lipid accumulation in rats, while oxymatrine could improve glucose tolerance and alleviate hepatic steatosis in rats. High fructose feeding stimulated the protein expressions of key lipid-synthesis enzymes, which were decreased by oxymatrine intervention. Both high fructose feeding and oxymatrine intervention had no significant effect on protein expressions of mitochondrial fatty acid oxidation enzymes.

关 键 词：氧化苦参碱 甘油三酯 脂肪肝 

分 类 号：R285.5[医药卫生—中药学]