GIRK4基因多态性与新疆维吾尔族人胰岛素抵抗的相关性研究  

Association between GIRK4 gene polymorphisms and insulin resistance in Xinjiang Uygur population

作　　者：李南方[1] 康永安[1] 张德莲[1] 王红梅[1] 张菊红[1] 胡燕荣[1] 洪静[1] 

机构地区：[1]新疆维吾尔自治区人民医院高血压中心,新疆高血压研究所 ,乌鲁木齐830001

出　　处：《中华医学遗传学杂志》2012年第6期715-719,共5页Chinese Journal of Medical Genetics

基　　金：基金项目：国家自然科学基金（81160109）

摘　　要：目的探讨G蛋白偶联内向整流钾通道（G-protein-activated inwardly rectifyingK’channel，GIRK4）基因多态性与新疆维吾尔族人胰岛素抵抗（insulin resistance，IR）的相关性。方法采取横断面流行病学调查为基础的病例一对照研究，随机选取1295位（324例IR患者和971名对照）新疆维吾尔族研究对象，随机抽取其中48例IR患者测序筛查维吾尔族人GIRK4基因功能区的变异位点，然后选取代表性的变异位点，在1295名研究对象中基因分型并进行关联分析研究。结果年龄≤50岁维吾尔族人群中，rs11221497位点变异与IR相关（基因型模型P=0．017，显性模型中P=0．009），Logistic分析校正混杂因素（年龄、性别、吸烟、饮酒）后，显性模型CC基因型携带者患IR的0R值为1．833（95％CI：1．157～2．905）。结论GIRK4基因多态性可能与新疆维吾尔族人IR相关；rs11221497位点CC基因型是IR的危险因素。Objective To assess the association between polymorphisms of G-protein-activated inwardly rectifying K＋ channel （GIRK4）gene and insulin resistance （IR） in Xinjiang Uygur population. Methods A cross-sectional epidemiological survey-based case-control study was carried out, for which 1295 subjects （including 324 IR patients and 971 non-IR controls） were randomly selected. Functional region of the GIRK4 gene was sequenced for 48 randomly selected IR patients. Representative variable sites were chosen, with its association with IR assessed in 1295 Uygur subjects. Results rsl1221497 variant was associated with IR in Uygur subjects under 50 years old （P- 0. 017 in genotype model, P=0. 009 in dominant model）. Subjects with dominant model of CC genotype have an OR of 1. 833 （95%CI： 1. 157-2. 905） for IR. Conclusion GIRK4 gene polymorphisms may be associated with IR in Uygur＇ ethnics from Xinjiang. The CC genotype of rs11221497 variant is a risk factor for IR.

关 键 词：GIRK4基因 单核苷酸多态性 新疆维吾尔族 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]