抗菌肽的作用机制、生物活性及应用研究进展  

Advances on mechanism,bioactivity and application of antimicrobial peptides

作　　者：柳江枫[1] 胡天驹[1] 彭宜红[1] 

机构地区：[1]北京大学医学部基础医学院,北京100191

出　　处：《微生物学免疫学进展》2012年第5期84-88,共5页Progress In Microbiology and Immunology

基　　金：国家自然科学基金国家基础科学人才培养基金(No.J1030831/J0108)资助

摘　　要：抗菌肽广泛存在于生物界,是辅助生物机体抵抗外来病原体入侵的重要防御分子。抗菌肽不仅能抑制、杀灭多种细菌,而且具有抗真菌、抗寄生虫、抗病毒、抗肿瘤和免疫调节等生物学活性。抗菌肽的作用机制与传统抗生素不同,不仅具有广谱抗微生物作用,而且不易诱导机体产生耐药性,因此,在治疗临床耐药菌株方面具有极大的开发潜力。Antimicrobial peptides are produced by almost all species of lives as an important molecule against pathogenetic microorganisms in host＇ s immune defense system. Antimicrobial peptides have biological activities on immunoregulation and the mechanism for unique effect of them contributes to a broad spectrum of resistance for bacteria, fungi, parasites, viruses and tumors with a low tendency of drug resistance, which has a great potential to develop a new type of peptide antibiotics against the increasing multi-drug resistant clinical infections. In this paperj the classification , structure-function relationship, effect mechanism and prospects for application are reviewed.

关 键 词：抗菌肽 构效关系 作用机制 生物活性 应用前景 

分 类 号：R978.1[医药卫生—药品]