小儿分泌性中耳炎与肿瘤坏死因子及免疫球蛋白的关系  

Interrelation of Recurrent Secretory Otitis Media with Tumor Necrosis Factor-α and Immunoglobulin

作　　者：邵佩芬[1] 莫薇[1] 陈黎勤[1] 

机构地区：[1]浙江大学医学院附属儿童医院,浙江杭州310003

出　　处：《科技通报》2000年第3期222-224,共3页Bulletin of Science and Technology

摘　　要：为探讨儿童分泌性中耳炎与肿瘤坏死因子及免疫球蛋白的关系 ,采用 EL ISA双抗体夹心法及免疫扩散试验 ,对 30例健康儿童和 37例分泌性中耳炎患儿进行肿瘤坏死因子 (TNF- α)和免疫球蛋白的测定 .结果分泌性中耳炎 TNF- α明显增高 (P<0 .0 1) ,Ig A明显降低 (P<0 .0 1) ,Ig G、Ig M无明显差异 .推测在分泌性中耳炎的发病过程中 。In order to explore the interrelation between secretory otitis media(SOM) with tumor necrosis factor α(TNF α) and immunoglobulin (IG),measurements were made on 30 healthy children and 37 SOM cases by using enzyme linked immunosorbent assay (ELISA) .The result showed that TNF α was significantly raised and IgA was lowered in SOM cases when compared with healthy cases( P <0.01).No statistical difference was observed in IgG and IgM between the two groups,suggesting that the immunoglogical mechanisms played a part in the SOM pathogeniesis.

关 键 词：分泌性中耳炎 肿瘤坏死因子Α 免疫球蛋白 儿童 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]