缺氧诱导因子在椎间盘退变过程中作用机制的研究进展  

Current researches on the action mechanism of hypoxia-inducible factor in pathological process of intervertebral disc degeneration

作　　者：任晋可[1] 李春海[1] 叶伟[1] 

机构地区：[1]中山大学孙逸仙纪念医院骨科,广州510120

出　　处：《中国骨科临床与基础研究杂志》2012年第5期388-392,共5页Chinese Orthopaedic Journal of Clinical and Basic Research

基　　金：国家自然科学基金(81101385);教育部博士点新教师基金(20090171120077);广东省自然科学基金(10151008901000084);广东省科技计划基金(2008B060600059;2009B060700097;201213031800359;201213031800360)

摘　　要：缺氧诱导因子(HIFs)是一类介导哺乳动物细胞内低氧反应的核转录复合体,目前的研究结果表明,其在椎间盘退变进程中起到重要作用。该文通过综述HIFs在椎间盘组织中的表达、调控以及与椎间盘细胞凋亡、自噬的关系,阐明其在椎间盘退变过程中的作用机制,从而为椎间盘退行性疾病的治疗开辟新思路和新途径。Recent researches demonstrate that the hypoxia-inducible factors（HIFs）,which are nuclear transcription complex that function as master regulators of hypoxia response in mammal cells,play an important role in the pathological process of intervertebral disc degeneration（IDD）.This paper reviewed the expression and regulation of HIFs in intervertebral disc tissues,as well as the relationship between HIFs and the apoptosis and autophagy of intervertebral disc cells,clarified the action mechanism of HIFs during IDD pathological process,thus provided new ideas and new approaches for IDD treatment.

关 键 词：椎间盘 椎间盘退化 缺氧诱导因子 基因表达调控 凋亡 自噬 

分 类 号：R681.53[医药卫生—骨科学]