肺炎支原体肺炎患儿细胞免疫功能的变化及脾氨肽的辅助治疗作用  

Changes of cellular immune function in children with mycoplasma pneumoniae pneumonia and the adjuvant effect of spleen aminopeptide.

作　　者：胡晓艳[1] 钱卫疆[1] 张双船[1] 李健雄[1] 林月钰[1] 

机构地区：[1]北京大学深圳医院儿科,广东深圳518036

出　　处：《海南医学》2012年第21期5-7,共3页Hainan Medical Journal

摘　　要：目的探讨肺炎支原体肺炎(MPP)患儿细胞免疫功能的变化及脾氨肽对MPP的辅助治疗作用。方法 62例MPP病例随机分成MPP治疗组30例和MPP对照组32例,并以同期体检的26例健康儿童作为健康对照组。所有MPP病例均予阿奇霉素口服治疗,MPP治疗组同时加用脾氨肽口服治疗。在MPP急性期及治疗后分别进行T淋巴细胞亚群检测,并观察MPP病例临床症状体征恢复的情况。结果 MPP患儿的CD3+、CD4+淋巴细胞比例及CD4+/CD8+低于健康对照组,CD8+比例高于健康对照组(P<0.05)。治疗后MPP治疗组CD3+、CD4+淋巴细胞比例及CD4+/CD8+高于MPP对照组,CD8+比例低于MPP对照组(P<0.05)。MPP治疗组症状体征较MPP对照组恢复快(P<0.05)。结论 MPP患儿细胞免疫功能受到抑制,脾氨肽可提高机体细胞免疫功能,对MPP有较好的辅助治疗作用。Objective To investigate the changes of cellular immune function in children with mycoplasma pneumoniae pneumonia （MPP） and the adjuvant effect of spleen aminopeptide. Methods Sixty-two patients of MPP were randomly divided into group A （n=30） and group B （n=32）, and 26 healthy children who had physical examination during the same period were enrolled as the control group. The patients in group A were treated with Azithromycin combined with spleen aminopeptide orally, while those in group B were given Azithromycin only. T lymphocyte subgroups of MPP were determined in the acute phase and after treatment, and the recovery of symptoms and signs of MPP were observed. Results The percentage of CD3＋, CD4＋ lymphocytes and the ratio of CD4＋/CD8＋ lymphocytes in the acute phase of MPP were significantly lower than those in the control group （P0.05）, while the percentage of CD8＋ lymphocytes in the acute phase of MPP was significantly higher than that in the control group （P0.05）. After treatment, the percentage of CD3＋, CD4＋ lymphocytes and the ratio of CD4＋/CD8＋ lymphocytes in group A were significantly higher than those in group B （P0.05）, with the percentage of CD8＋ lymphocytes significantly lower （P0.05）. The symptoms and signs recovered faster in group A than group B （P0.05）. Conclusion The cellular immune function is depressed in children with MPP. Spleen aminopeptide can improve the cellular immune function of the body, and has a good adjuvant effect for MPP.

关 键 词：肺炎支原体肺炎 细胞免疫功能 脾氨肽 

分 类 号：R725.6[医药卫生—儿科]