从血压分层的角度观察益糖康对痰热互结型并有IGR的代谢综合征患者的临床疗效  

Observation on Clinical Efficacy of Chinese Medicine Yitangkang on MS Patients with Phlegm-Heat Accumulation and IGR from the Perspective of Blood Pressure Stratification

作　　者：陈红谨[1] 石岩[1] 杨宇峰[1] 王莉[2] 张冰冰[1] 刘小溪[2] 刘亮[1] 徐鹏[1] 姜楠[1] 郭建彪[1] 秦伟锋[1] 连捷[1] 王宏涛[1] 朱克[1] 冀天威[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032 [2]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《辽宁中医杂志》2012年第11期2173-2175,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家科技部"十一五"国家科技支撑计划(2007BAI20B103)

摘　　要：目的:从血压分层的角度观察益糖康治疗并有IGR的MS患者的临床疗效,并探讨疗效的机制及并有IGR的MS与血压之间的关系。方法:把收治的痰热互结型并有IGR的代谢综合征患者165例,随机分成治疗组和安慰剂组,给予益糖康治疗12周后,测量FPG、2hPG、TG、TC、HDL-C、LDL-C、BMI。结果:(1)与治疗前比较,治疗组和安慰剂组的收缩压和舒张压均有明显改善,P<0.01,但组间比较治疗组明显优于安慰剂组,P<0.01;(2)血压未分层时,中药益糖康能降低空腹血糖、餐后血糖、BMI、TC、TG、HDL-C、LDL-C(P<0.01,0.05);血压≥140mmHg/90mmHg时,中药益糖康能降低患者的FPG、2hPG、TG、TC、LDL-C、BMI(P<0.01,0.05),血压<140mmHg/90mmHg时,中药益糖康能降低空腹血糖、餐后血糖和BMI(P<0.01,0.05)。结论:(1)痰热互结型并有IGR的MS患者以高血压型为主。(2)中药益糖康可以显著改善患者的餐后血糖、TC、TG、血压和BMI,但对高血压组患者的空腹血糖、餐后血糖、BMI疗效更佳。Objective：The perspective from the blood pressure stratification was for observing the clinical efficacy of Chinese medicine Yitangkang in MS patients with phlegm-heat accumulation and IGR,and explore the efficacy mechanism and the relationship between blood pressure and MS with IGR.Methods：165 cases of the MS with IGR were randomly divided into treatment group and placebo group.Chinese medicine Yitangkang was given for 12 weeks,and after treatment FPG,2Hpg,TG,TC,HDL-C and BMI were measured.Results：（1）Compared with that before treatment,the systolic and diastolic blood pressure of treatment group and placebo group were significantly improved（P〈0.01）,but the treatment group was significantly superior to the placebo group.（2）When blood pressure was not stratified,Chinese medicine Yitangkang can lower FPG,2hPG,BMI,TC,HDL-C and LDL-C（P〈0.01,P〈0.05）.When BP≥140mmHg/90mmHg,Chinese medicine Yitangkang can reduce FPG,2hPG,BMI,TC,and LDL-C（P〈0.01,P〈0.05）;BP140mmHg/90mmHg,Chinese medicine Yitangkang can lower FPG,2hPG and BIM（P〈0.01,P〈0.05）.Conclusion：（1）High blood pressure type is the main in the phlegm-heat accumulation syndrome of MS patients with IGR.（2）Chinese medicine Yitangkang can significantly improve the patients＇ 2hPG,TC,TG,blood pressure and BMI,but it has better efficacy on the hypertensive patients＇ FPG,2hPG and BMI.

关 键 词：中药益糖康 高血压 代谢综合征 

分 类 号：R544.1[医药卫生—心血管疾病]