“和血生络法”对心梗大鼠血管内皮功能的影响  

Effects of Huoxue Shengluo Formula on VEGF in Serum of Myocardial Infarction Rats

作　　者：侯仙明[1] 王亚利[1] 刘彦卿[2] 王文智[1] 方敬[1] 贾云芳[1] 

机构地区：[1]河北医科大学,河北石家庄050017 [2]白求恩国际和平医院,河北石家庄050082

出　　处：《辽宁中医杂志》2012年第11期2300-2301,共2页Liaoning Journal of Traditional Chinese Medicine

基　　金：河北省自然科学基金资助项目(C2008000723)

摘　　要：目的:通过观察"和血生络方"对血清中NO、NOS的影响,探讨"和血生络法"促血管新生作用是否与改善血管内皮功能有关。方法:选雄性Wistar大鼠,制作心肌梗死大鼠模型,随机分为消心痛组、和血生络高、低剂量组及模型组,同时建立假手术组,每组12只。药物治疗组分别给予和血生络水溶液(9.9g·kg-1·d-1,19.8g·kg-1·d-1)及消心痛水溶液(2.7mg·kg-1·d-1)每天1次灌胃,其他组给予等量蒸馏水,连续用药4周后处死大鼠,检测血清中NO、NOS的含量。结果:和血生络高、低剂量组及消心痛组血清中NO、NOS含量明显高于模型组(P<0.05),和血生络高剂量组优于其它处理组(P<0.05)。结论:"和血生络法"促血管新生的作用与改善血管内皮功能有关。Objective：To observe the effect of Huoxue Shengluo formula on NO and NOS and to investigate its mechanism on improving angiogenesis of myocardium of infarcted rats.Methods：Myocardium of infarcted rats model was made by Wistar rats.They were randomly divided into four groups which were model group,ID group,Huoxue Shengluo formula high and low dose groups.Sham operation group was made at the same time.Each group had 12 rats.Subsequently drug treatment groups were administrated with ID water solution in accordance with 2.7mg·kg^-1·d^-1and Huoxue Shengluo formula water solution in accordance with 9.9g·kg^-1·d^-1,19.8g·kg^-1·d^-1.The model group and sham group were treated with distilled water with the equal volume.Rats were treated once a day by intragastric administration.After 4 weeks,the rats were executed.The contents of serum NO and NOS were evaluated.Results：The NO and NOS contents of all treatment groups were higher than that of model group（P〈0.05）.High-dose group was better than low-dose group and ID group（P〈0.05）.Conclusion：The role to promote angiogenesis of Huoxue Shengluo formula is relevant to vascular endothelium function improvement.

关 键 词：和血生络法 心梗大鼠 血管内皮功能 一氧化氮 一氧化氮合酶 

分 类 号：R542.22[医药卫生—心血管疾病]