乙型肝炎患者病毒血清标志物的检测结果分析  

The analysis of the test results of virus serum markers for patients with hepatitis B

作　　者：殷勤[1] 盛磊[2] 

机构地区：[1]新疆石河子市中心血站,新疆石河子832000 [2]新疆石河子大学医学院第一附属医院检验科

出　　处：《现代预防医学》2012年第23期6254-6255,6258,共3页Modern Preventive Medicine

摘　　要：目的分析乙型肝炎患者病毒血清标志物类型,为搞好乙型肝炎病毒预防工作提供更准确的依据。方法采集678份HBV患者血清,采用酶联免疫吸附试验(ELISA)和时间分辨免疫荧光分析法(TRFIA)检测HBV血清标志物。结果①678例HBV感染患者病毒血清标志物(HBV-M)表现模式有12种,其中最主要模式为A模式,占74.04%。其次为小三阳(HBsAg、抗-HBe、抗-HBc同时阳性者)53例,大三阳(HBsAg、HBeAg和抗-HBc同时阳性)居第4位20例。②本组患者性别分布中单独HBsAb阳性模式、大三阳和小三阳及其他感染模式,男性均约为女性的两倍,提示男性是预防HBV感染的重点对象。③单独HBsAb阳性和在青少年与儿童(﹤20岁)中的比率较其他年龄低,小三阳在青少年中感染比率为25.00%,提示青少年依然是HBV感染的重点预防对象。结论本地区HBV人群HIⅣ-M表现模式呈现多样性组合模式,主要为单独HBsAb阳性模式,男性感染约为女性的两倍,小三阳在青少年中感染比率较高,应重视男性和青少年的预防工作。OBJECTIVE To analyze the type of virus serum markers for patients with hepatitis B and provide a more accurate basis for doing a good job of hepatitis B virus prevention. METHODS 678 cases of HBV serum were collected, the enzymelinked immunosorbent assay （ELISA） and time-resolved fluoroimmunoassay （TRFIA） were used for the detection of serum HBV markers. RESULTS ① In the 678 cases of HBV infection in patients with virus serum markers （HBV-M）, there were 12 kinds of performance mode. A mode was the most important mode, accounting for 74.04%. Followed by HBeAb （HBsAg, antiHBe, anti-HBc positive） of 53 cases, HBeAg （HBsAg, HBeAg and anti-HBc positive） ranked fourth in the 20 cases. ② The gender distribution of alone HBsAb positive mode, HBeAb and HBeAg, the male was about twice of female. It suggested that the male was the focus of prevention of HBV infection. ③ The alone positive HBsAb and the ratio in adolescents and children （﹤20 years） were lower than any other ages in young people. The infection rate of HBeAb was 25.00%. It prompted that the young was still the focus for prevention of HBV infection. CONCLUSION HI Ⅳ-M performance model in HBV populations in the region shows the diversity of combinations, it mainly is a separate HBsAb positive mode, male is approximately twice of female that infected. The infection rate of the male and the young is higher. The prevention job for the male and young should be paid more attention.

关 键 词：乙型肝炎 血清标志物 检测结果 

分 类 号：R373.21[医药卫生—病原生物学]