飞龙掌血水提物对正常猫心功、血液动力学的影响  

The effects of aqueous extract from Toddalia Asiatica on cardiac function and hemodynamics in normal cats

作　　者：任先达[1] 叶开和[1] 熊爱华[1] 杨延秀[1] 

机构地区：[1]暨南大学医学院药理学教研室,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2000年第2期1-4,共4页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：广东省中医药管理局科学基金!(96141)

摘　　要：观察飞龙掌血（ Ｔａｄｄａｌｉａ ａｓｉａｔｉｃａ Ｌａｍ）水提物（飞龙一号， Ｆ０１）对正常动物心脏功能和血液动力学的影响。方法：正常家猫麻醉后开胸，在人工呼吸下观测用药前后动物左心室内压、左室舒张末期压、心室内压变化速率、动脉血压、心输出量和心率等各项参数的变化。结果：两种剂量（７３．５、 １２７ｍｇ／ｋｇ）的 Ｆ０１静脉注射后，显著降低 ＬＶＰ、ＴＰＶＲ、ＳＢＰ、ＤＢＰ、ＭＢＰ、ＬＶＷＩ、ＴＴＩ和 ｄｐ／ｄｔ_(ｍａｘ)（Ｐ＜０．０５或 Ｐ＜０．０１）；ＴＦＩ×ＨＲ、－ｄｐ／ｄｔ_(ｍａｘ)、ＣＯ、ＣＩ和 ＳＩ在使用 Ｆ０１ １２７ ｍｇ／ｋｇ后有显著性降低（Ｐ＜０．０５或Ｐ＜０．０１），但在使用小剂量Ｆ０１（７３．５ｍｇ／ｋｇ）后变化不显著（Ｐ＞０．０５）；ｔ－ｄｐ／ｄｔ_(ｍａｘ)和Ｖｃｅ－ＣＰＩＰ在用药后稍有下降（Ｐ＞０．０５）；ＬＶＥＤＰ和ＨＲ几乎无变化。结论：Ｆ０１除扩张外周血管降低心脏的后负荷外，对心脏有明显抑制作用，从而显著减少心肌作功和耗氧，可能是其抗心肌缺血的另一作用机制。Aim: To observe foe effects of toddalia asiatica aqueous extract(Fei Long No 1, F01 ) on cadiac function and hemodynamics in normal animal. Methods: Two doses(73. 5, 127 mg/kg) of F01 were injected per femoral vein into the anesthetized open - chest cats, LVP. LVEDP. dp/dt \ BP. CO and HR were performed before and after administration of F01. t - test paired was used for the statistical analysis. Results: All two doses of F01 significantly reduced various indices as follows: LVP, TPVR, SBP, DBP, MBP, LVWI, TTI and dp/dt_(max). But only F01 127 mg/kg induced a significant decrease in TTI x HR, - dp/dt_(max), CO, CI and SI. These effects were correlated with the dosage. Vce - CPIP, and t - dp/dt_(max) had not marked changes. LVEDP and HR had ode little change. Conclusion: F01 has inhibited at the heart markedly besides vasodilative effect, so that the left ventricle work and consumption of oxygen are ruduced significantly. These are probable the mechanism of the protective effect of F01 on myocrdial ischemia.

关 键 词：飞龙掌血 水提物 心功能 血液动力学 中药 

分 类 号：R285.5[医药卫生—中药学]