咪达唑仑在肝衰竭人工肝治疗中的镇静作用  

Sedative effectes of midazolam in the treatment of hepatic failure patients with hepatic coma by artificial liver

作　　者：蒲云川[1] 陈凯红[1] 毛燕群[1] 张英[1] 杨美蓉[1] 尹翠兰[1] 李超[1] 

机构地区：[1]无锡市第五人民医院重症肝病科ICU,江苏无锡214005

出　　处：《中国临床药理学杂志》2012年第11期806-808,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的观察咪达唑仑在肝衰竭肝昏迷患者行人工肝治疗时的镇静作用。方法 28例极度躁动影响人工肝治疗操作的患者,初始给予咪达唑仑3 mg静脉推注;继而根据患者躁动情况以1 mg.h-1持续或间断静脉泵入,每天给予总量不超过15 mg。结果初始给予咪达唑仑3 mg,可迅速达到满意镇静深度;继而给予1 mg.h-1,可有效维持人工肝治疗顺利进行。但有2例出现一过性血压下降,暂停即可纠正;均未出现呼吸抑制。结论咪达唑仑可对肝衰竭肝昏迷患者行人工肝治疗时的辅助镇静作用是有效和安全的。Objective To examine sedative effectes of midazolam in the treatment of hepatic failure patients with hepatic coma by artificial liver.Metheds Twenty-eight extreme restless patients were chosen for this study.All cases were injected initial 3 mg midazolam,and then 1 mg·h-1 dose were pumped last or intermittently according to patients with restless circumstance,every day the total amount to no more than 15 mg.Results The initial use of 3 mg doses can quickly achieve satisfaction calm depth,continuous intravenous pump of 1 mg·h-1 doses can maintain effective artificial liver treatment.In 28 cases,2 cases of patients had the temporary decrease of blood pressure which can be corrected by stoping the drug.All cases did not appear respiratory inhibition.Conlusion It is safe and sedative effective of midazolam in the treatment of hepatic failure patients with hepatic coma by artificial liver.

关 键 词：咪达唑仑 镇静 肝衰竭 肝昏迷 人工肝治疗 

分 类 号：R971.3[医药卫生—药品] R575.3[医药卫生—药学]