头孢卡品酯对细菌感染小鼠败血症的体内抗菌作用  

In vivo activity of cefcapene proxetil in the experimental model of mouse septicemia infected by bacteria

作　　者：钟巍[1] 李耘[1] 吕媛[1] 李曼宁[1] 刘健[1] 

机构地区：[1]北京大学第一医院临床药理研究所,北京100034

出　　处：《中国临床药理学杂志》2012年第11期825-827,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的评价头孢卡品酯对我国近年临床分离致病菌所致小鼠败血症的体内抗菌作用。方法以最小致死量(MLD)0.5 mL腹腔注射细菌感染小鼠,建立小鼠败血症实验模型。对4株临床分离致病菌进行了体内保护试验。灌胃不同剂量的抗菌药物0.5 mL,记录给药后1-7天内小鼠成活率,用BLISS法计算50%,95%有效剂量(ED50、ED95)。结果头孢卡品酯对不产ESBLs的大肠埃希菌、肺炎克雷伯菌以及甲氧西林敏感金葡菌、青霉素敏感肺炎链球菌的ED50值在0.38～3.61 mg.kg-1,ED95值在1.30～17.94 mg.kg-1。结论头孢卡品酯体内对革兰阴性菌作用优于革兰阳性菌。Objective To evaluate the in vivo activity of cefcapene prox- etil in the experimental therapy of mouse septicemia caused by clinical iso- lated pathogenic bacteria in recent years in China. Methods The mice were intraperitoneally injected with 0. 5 mL minimum lethal dose （MLD） bacteria and experimental model of mouse septicemia was established. Cef- capene proxetil and cefpodoxime proxetil were each oral administered in a single dose. The survival of the infected mice were monitored for 7 days, and the 50%, 95% effective dose （EDs0, ED95 ） was determined by the BLISS method. Results The EDs0 and ED95 of cefcapene proxetil against extended - spectrum beta ＇ lactamase （ESBL） negative Escherichia coli, ESBL negative Klebsiella peumoniae, methicillin susceptibility Staphylococcus aureus （MSSA） and penicillin susceptibility Streptococcus pneumoniae were 0. 27 ~8. 08 mg ~ kg-1 and 2. 31 ~25. 45 mg . kg-1, which were almost the same as that of cefpodoxime proxetil. Conclusion Cefcapene proxetil showed a good in vivo activity for gram -positive and negative bacterial.

关 键 词：头孢卡品酯 败血症 体内抗菌作用 

分 类 号：R978.11[医药卫生—药品] R965.1[医药卫生—药学]