石榴皮水提物对束缚浸水应激大鼠胃肠运动机能的影响  

Effects of aqueous extraction from pomegranate peel on gastrointestinal motility function in restraint and water-immersion stress rat

作　　者：张爱丽[1] 刘姗姗[1] 崔希云[1] 艾洪滨[1] 

机构地区：[1]山东师范大学生命科学学院解剖生理学教研室,济南250014

出　　处：《中国临床药理学杂志》2012年第11期828-830,共3页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(31071920);山东省教育厅科技计划基金项目项目(J08LE63)

摘　　要：目的研究石榴皮水提物(AEPP)对束缚-浸水应激(简称应激)大鼠胃肠运动的影响。方法 Wistar雄性大鼠随机分为空白对照组、对照Ⅰ组(三蒸水)、对照Ⅱ组(三蒸水+应激)、对照Ⅲ组(5000mg.kg-1除多酚AEPP+应激)和实验Ⅰ、Ⅱ、Ⅲ(50,500,5000 mg.kg-1AEPP+应激)组,观察其胃溃疡指数和胃肠的运动。结果与对照Ⅱ组比较,实验Ⅱ、Ⅲ组的胃黏膜损伤指数明显减少,胃内残留率明显增多,小肠推进率明显降低,排便时间明显延长(均P<0.05,P<0.01)。结论石榴皮多酚对应激性胃黏膜损伤、胃肠道运动机能紊乱有良好的预防作用。Objective To observe the effect of aqueous extraction from pomegranate peel（AEPP） on the gastrointestinal motility function in restraint and water-immersion stress（RWIS） rats.Method Male Wistar rats were randomly divided into blank group,control Ⅰgroup（double distilled water,DDW）,control Ⅱgroup（DDW＋RWIS）,control Ⅲgroup（5000 mg·kg-1 except polyphenols of AEEP＋ RWIS） and testⅠ,Ⅱ,Ⅲ groups（50,500,5000 mg·kg-1 AEPP＋RWIS）.The rats of each group were given drug by intragastric administration,and then treated with RWIS.The gastric ulcer index and gastrointestinal motility were observed.Results Compared with control groupⅡ,the gastric ulcer index and intestinal propulsive rate in testⅡ,Ⅲ groups decreased significantly,and the gastric remnant rate,the time of defecation significantly increased（P0.05,P0.01）.However,the ControlⅢgroup had no such phenomenon.Conclusion The AEPP could be a prodrug with preventive effect to stress gastric mucosal lesion and gastrointestinal motility disorder.

关 键 词：石榴皮水提物 胃溃疡 胃排空 小肠推进 

分 类 号：R285.5[医药卫生—中药学] R965.1[医药卫生—中医学]