新型氨基化磁性树状分子纳米颗粒的制备与表征  

Synthesis and characterization of newly aminated magnetic dendrimer nanoparticles

作　　者：王秀玲[1,2] 顾银君[1,2] 庄虹[1,2] 赵勤[3] 顾亚琼[1] 马倩[1] 刘勇健[1,2] 

机构地区：[1]苏州科技学院化学与生物工程学院,苏州215009 [2]江苏省环境功能材料重点实验室,苏州215009 [3]苏州大学材料与化学化工学部,苏州215123

出　　处：《化工新型材料》2012年第11期61-63,共3页New Chemical Materials

基　　金：国家自然科学基金资助项目(51103120);苏州科技学院研究生创新(2011)资助项目(SKCX11S-055)

摘　　要：采用化学共沉淀法,以FeCl3.6H2O和FeSO4.7H2O为原料制备磁性Fe3O4纳米颗粒,采用3-氨丙基三乙氧基硅烷(APTES)、丙烯酸丁酯(BA)和无水乙二胺(EDA)对其进行修饰,制备了三代表面氨基化的磁性Fe3O4树状分子纳米颗粒,并对其进行结构表征与性能测试。结果表明:树状分子逐代修饰在磁性颗粒表面,氨基含量逐代增加,分别为0.41、0.69和0.87mmol/g;Fe3O4纳米颗粒平均尺寸在12nm左右,修饰后的三代磁性纳米颗粒的粒径逐代增加,分别为14、27和40nm左右;三代产品仍具备较高的饱和磁化强度,展现出了典型的超顺磁性。这种氨基功能化的磁性纳米粒子在细胞分选、固定化酶和靶向药物等诸多领域有着巨大应用潜力。The synthesis of three generations of newly aminated magnetic dendrimer nanoparticles was demonstrated.Superparamagnetic Fe3O4 nanoparticles were first synthesized by hydrothermal coprecipitation of ferric and ferrous ions,followed by the modification of their surfaces with 3-aminopropyltriethoxy-silane（APTES）,butyl acrylate（BA）and ethylenediamine（EDA）.The structure and properties of as-synthesized nanoparticles were characterized by FTIR,EA,TEM,vibrating sample magnetometer（VSM）et al.The result showed that Fe3O4 nanoparticles were coated successfully by dendrimer from generation to generation.The amino group content of the resulting products was increased from 0.41 to 0.87mmol/g after the last generation.The Fe3O4 nanoparticles had a typical diameter of 12nm,and then the average size was increased with increasing generation and reached 40nm after the last generation.Moreover,three generations of the nanoparticles still retained superparamagnetic behavior at room temperature.The nanoparticles could be widely used in cell sorting,immobilized enzyme,targeted medicine and so on.

关 键 词：磁性 树状分子 纳米颗粒 氨基化 表面修饰 

分 类 号：TB383.1[一般工业技术—材料科学与工程]