208痛风合剂治疗痛风性关节炎的临床研究  

Clinical study on the curative effect and safety of 208 gout drug combinations in the treatment of gouty arthritis

作　　者：姬艳波[1] 韩宏妮[1] 陈立忠[1] 王海燕[1] 

机构地区：[1]中国人民解放军第208医院,吉林长春130062

出　　处：《中医正骨》2012年第10期20-25,共6页The Journal of Traditional Chinese Orthopedics and Traumatology

摘　　要：目的:观察208痛风合剂治疗痛风性关节炎的临床疗效和安全性。方法:132例痛风性关节炎患者,均为男性;年龄45～60岁,中位数46.5岁;病程3 d至5年,中位数3.5年。急性痛风性关节炎患者60例,中医辨证均为湿热蕴结证,随机分为2组,治疗组33例,208痛风合剂1号口服及外敷患处治疗;对照组27例,口服秋水仙碱片及依托考昔片治疗;两组均治疗7 d。慢性痛风性关节炎患者72例,中医辨证均为痰浊阻滞证,随机分为2组,治疗组37例,口服208痛风合剂2号治疗;对照组35例,口服苯溴马隆片治疗;两组均治疗20 d。治疗结束后观察各组患者疗效、不良反应发生率及各项化验指标改善情况。结果:急性痛风性关节炎患者治疗7 d后,治疗组治愈18例,显效13例,有效2例;对照组治愈10例,显效14例,有效3例;2组疗效比较差异无统计学意义(Z=-1.251,P=0.178)。治疗组未发生药物不良反应;对照组出现腹泻2例,呕吐2例,皮疹2例;2组不良反应发生率比较,差异有统计学意义(P=0.006)。治疗组患者血尿酸[(375.69±110.99)μmol.L-1]、C反应蛋白[(35.61±18.67)mg.L-1]、血沉[(23.12±15.83)mm.h-1]均较治疗前[(474.05±89.67)μmol.L-1、(60.46±13.99)mg.L-1、(39.67±16.46)mm.h-1]降低(t=6.256,P=0.000;t=6.119,P=0.000;t=4.163,P=0.001),尿液pH值(6.13±0.44)较治疗前(5.81±0.39)升高(t=3.126,P=0.004);血肌酐[(98.62±17.37)μmol.L-1]、血尿素氮[(4.84±1.49)mmol.L-1]与治疗前[(99.13±11.81)μmol.L-1、(5.44±0.99)mmol.L-1]相比,差异无统计学意义(t=0.139,P=0.912;t=1.927,P=0.073)。对照组患者血尿酸[(380.41±116.78)μmol.L-1]、C反应蛋白[(37.16±19.11)mg.L-1]、血沉[(24.73±17.13)mm.h-1]均较治疗前[(469.85±90.21)μmol.L-1]、C反应蛋白[(61.06±12.14)mg.L-1]、血沉[(38.97±17.58)mm.h-1]降低(t=5.065,P=0.000;t=5.487,P=0.000;t=3.015,P=0.005);血肌酐[(97.98±20.14)μmol.L-1]、血尿素氮[(4.95±1.62)mmol.L-1]、尿液pH值(6.02±0.51)与治疗前[(98.97±12.45)μmol.L-1、(5.29±1.12Objective：To observe the clinical curative effect and safety of 208 gout drug combinations in the treatment of gouty arthritis.Methods：One hundred and thirty-two patients with gouty arthritis were all males,ranging in age from 45 to 60 years with a median of 46.5 years,ranging in courses of disease from 3 days to 5 years with a median of 3.5 years.Sixty patients with acute gouty arthritis diagnosed as syndrome of accumulated dampness-heat by TCM differentiation were randomly divided into 2 groups,thirty-three cases in the treatment group were administrated with oral application of 208 gout drug combinations No.1 combined with external application on affected parts,while the others in the control group were administrated with oral application of colchicine tablets and etoricoxib tablets,and cases in the 2 groups were all treated for 7 days.Seventy-two patients with chronic gouty arthritis diagnosed as syndrome of phlegm stasis by TCM differentiation were randomly divided into 2 groups,thirty-seven cases in the treatment group were administrated with oral application of 208 gout drug combinations No.2,while the others in the control group were administrated with oral application of benzbromarone tablets,and cases in the 2 groups were all treated for 20 days.The curative effect,incidence rate of adverse effects and improvements of each laboratory indicator of patients in all the groups were observed after the treatment. Results：After 7-day treatment for the acute gouty arthritis,18 patients got an excellent result,13 good,and 2 fair in treatment group;while 10 patients got an excellent result,14 good,and 3 fair in control group;there was no statistical difference in curative effect between the 2 groups（Z=-1.251,P=0.178）.No adverse drug reactions were found in treatment group,while 2 cases with diarrhea,2 cases with vomiting and 2 cases with rash were found in control group;there was statistical difference in incidence rate of adverse effects between the 2 groups（P=0.006）.For patients in the treatment g

关 键 词：关节炎 痛风性 高尿酸血症 治疗 临床研究性 208痛风合剂 

分 类 号：R259[医药卫生—中西医结合]