皮肤慢性移植物抗宿主病1例并文献复习  

Chronic cutaneous graft-versus-host disease:a case report and literature review

作　　者：熊晓刚[1] 刘业强[1] 徐晓[2] 刘波[1] 雷晴[1] 卢军[1] 余泽莹[1] 陈方元[1] 涂圣安[1] 

机构地区：[1]九江学院附属医院皮肤科,江西九江332000 [2]九江学院附属医院病理科,江西九江332000

出　　处：《临床皮肤科杂志》2012年第12期730-731,共2页Journal of Clinical Dermatology

摘　　要：报告1例皮肤慢性移植物抗宿主病。患者男,25岁。全身泛发性皮损5年,主要表现为全身弥漫性色素减退伴色素加深的苔藓样斑片。面部呈现激素依赖性皮炎样表现。毛发稀疏,眉毛和腋毛脱落,睫毛及阴毛发白。手(足)指(趾)甲失去光泽,表面有纵嵴,部分缺损、萎缩。臀部皮损组织病理检查表现为苔藓样浸润模式。诊断:皮肤慢性移植物抗宿主病。给予糖皮质激素及他克莫司系统治疗,皮损改善不明显。A 25-year-old man presented with a 5-year history of hyperpigmented and hypopigmented lichenoid skin lesions all over the body. There was steroid-dependent dermatitis-like manifestation on the face. Hair loss was evident on the scalp, eyebrows, armpit. Eyelashes and pubic hairs were white. Nail changes included brittleness, roughness, longitudinal ridges, and onychomadesis and onychatrophia. Histopathology of skin lesions on the buttocks revealed a pattern of lichenoid infiltration. The diagnosis was made as chronic cutaneous Graft-versus-host disease. The patient received daily oral corticosteroids in combination with systemic tacrolimus. No improvement had been obtained.

关 键 词：移植物抗宿主病 慢性 皮肤 

分 类 号：R758.29[医药卫生—皮肤病学与性病学]