AMI患者ALOX5AP基因SG13S114位点SNP与ARPs的关系  

The Relationship between SG13S114 SNP on gene ALOX5AP and ARPs of AMI

作　　者：孙晓盈[1] 谢风[1] 金玲[1] 王海[1] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130033

出　　处：《中国实验诊断学》2012年第11期2042-2044,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技发展计划项目(200905168)

摘　　要：目的研究心肌梗死(AMI)患者ALOX5AP基因SG13S114位点单核苷酸基因多态性(SNP)与急性时相反应蛋白(ARPs)的关系。方法分别采用限制性长度多态性聚合酶链反应(RLFP)方法,免疫比浊法研究ALOX5APSG13Sll4A/T的SNP及ARPs包括纤维蛋白原(fbg),高敏C反应蛋白(hs-CRP)的关系。结果心肌梗死组与冠心病组患者外周血基因组ALOX5AP基因SG13S114位点SNP分布T/T,T/A,A/A具有显著性差异(P<0.05;ALOX5AP基因SG13S114A/A型的AMI患者中FBg和hs-CRP显著高于对照组。结论 ALOX5AP基因SG13S114A/A可能是中国人群AMI发病的遗传性危险因素,也是影响AMI患者预后的重要炎症性因素。Objective To investigate the relationship between gene frequency、allele frequency of SG13S114 SNP on ALOX5APand pathological change degree of myocardial infarction（MI）、blood plasma ARPs Methods Adopt molecular biology –restricted length polymorphism reaction and immunoturbidimetry.Results There is significant difference on polymorphism of DNA ALOX5A SG13S114 SNP T/T,T/A,A/A between two groups（P0.05）;and the level of FBgand hs-CRP of AMI group is higher than control one.Conclusion Allelotype SG13S114A/A of DNA ALOX5AP is probably inherited risk factor of AMI;and is also a infl.Factor that can affect recovery of AMI

关 键 词：5-脂氧合酶激活蛋白 纤维蛋白原 超敏C反应蛋白 限制性长度多态性聚合酶链反应 基因多态性 

分 类 号：R542.22[医药卫生—心血管疾病]