胱抑素c、C反应蛋白、尿β2微球蛋白在高血压肾损伤诊断的临床应用  

Clinical application of cystatin C,C reactive protein,B2 urine microglobulin in the diagnosis of hypertensive renal injury

作　　者：秦望森[1] 邓予晖[1] 刘章锁[2] 

机构地区：[1]河南省人民医院检验科,河南郑州450003 [2]郑州大学第一附属医院肾内科

出　　处：《中国实验诊断学》2012年第11期2058-2060,共3页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助(81070574)

摘　　要：目的探讨胱抑素(Scy-c)、C反应蛋白(CRP)、尿β2微球蛋白(β2-MG)在高血压肾损伤诊断的临床应用价值。方法选择我院197例原发性高血压患者为研究对象,以89例健康体检人员为对照,研究高血压不同严重程度组别及高血压不同肾功能组别与对照组Scy-c、CRP、尿β2-MG浓度比较。结果高血压不同严重程度组别及对照组Scy-c、CRP、尿β2-MG有统计学差异,随血压升高Scy-c、CRP、尿β2-MG均升高;高血压不同肾功能组别及对照组Scy-c、CRP、尿β2-MG比较均有统计学差异;随高血压肾功能的受损,Scy-c、CRP、尿β2-MG进行性升高。结论 Scy-c、CRP、尿β2-MG是高血压早期肾功能受损良好的指标。Objective To explore the clinical application value of cystatin C（Scy-c）,C reactive protein（CRP）,B2 urine microglobulin（β2-MG） in the diagnosis of hypertensive renal injury.Methods 197 patients in our hospital in patients with essential hypertension as the object of study,and 89 cases of health physical examination personnel control,studied on hypertension in different groups and different severity of hypertension renal functional groups and control group Scy-c,CRP,urinary β2-MG concentration comparison Results There was a statistically significant difference in Scy-c,CRP and urinary β2-MG between essential hypertension patients with different severity group and control group,Scy-c,CRP,urinary β2-MG increased with elevated blood pressure,hypertension of different renal function group and control group Scy-c,CRP,urinary β2-MG was significant difference;with hypertensive renal damage,Scy-c,CRP,urineβ 2-MG were increased.Renal hypertension of different functional groups and control group Scy-c,CRP,urinary β2-MG was significant difference;Scy-c,CRP,urinary β2-MG were increased.with hypertensive renal damage.Conclusion Scy-c,CRP,urinary β2-MG is the essential hypertension patients with early renal function impairment good indicator.

关 键 词：胱抑素C C反应蛋白 尿B2微球蛋白 高血压 肾损伤 

分 类 号：R544.1[医药卫生—心血管疾病]