细胞表面抗原抗体相关脑炎  

Encephalitis associated with antibodies against neuronal cell surface antigens

作　　者：王佳伟[1] 宋兆慧[1] 

机构地区：[1]首都医科大学附属北京友谊医院神经内科,北京100050

出　　处：《中国实用内科杂志》2012年第11期826-829,共4页Chinese Journal of Practical Internal Medicine

摘　　要：由于人们对细胞表面抗原抗体相关脑炎的认识不足,延误诊治,对其预后造成不良影响。细胞表面抗原抗体相关脑炎的靶抗原,在突触传递、重塑和神经兴奋方面起着重要作用,包括N-甲基-D天冬氨酸(NMDA)受体、α-氨基-3-羟基-5-甲基-4-异恶唑基丙酸(AMPA)受体、γ-氨基丁酸B(GABAB)受体和其他自身抗原,如LGI1和Caspr2等。该类疾病主要涉及儿童和年轻人,病情较重,病程较长,可伴或不伴发肿瘤,早期治疗后预后较好,但存在复发趋势。文章旨在阐述该类疾病临床特征,诊断和治疗的新进展,以引起临床医生的关注。Since encephalitis associated with antibodies against neuronal cell surface antigens hasn＇t been known enough by people, it has always been delayed diagnosis and treatment, which results in an adverse effect on its prognosis. The target antigens of encephalitis associated with antibodies against neuronal cell surface antigens play an important role in synaptie transmission,plasticity and nerve excitability,including NMDAR, AMPAR, GABABR and other receptors such as LGI1 and Caspr2. This kind of disease mainly occurs in children and young people and has relatively severe disease degree and longer disease course,with or without tumor, which has a relatively good prognosis after treatment but has a trend of recurrence. In this study, the introduction of clinical characteristics and the update of diagnosis and treatment were highlighted so as to cause the concerns of clinicians.

关 键 词：神经元表面抗原抗体 AMPA受体 NMDA受体 GABAB 受体 LGI1 Caspr2 

分 类 号：R512.3[医药卫生—内科学]