FSHR基因Ala307Thr单核苷酸多态性与浆液性卵巢癌易感性的关联  

Single nucleotide polymorphism of Ala307Thr in FSHR gene and its relationship with susceptibility of serous ovarian cancer

作　　者：徐嬿[1] 金鸿雁[1] 李斌[1] 

机构地区：[1]复旦大学附属妇产科医院,上海200011

出　　处：《复旦学报（医学版）》2012年第6期600-604,共5页Fudan University Journal of Medical Sciences

摘　　要：目的探讨FSHR基因第10外显子Ala307Thr单核苷酸多态性与浆液性卵巢癌易感性的关联。方法采用病例对照研究方法,收集48例浆液性卵巢癌患者的卵巢组织和30例非妇科恶性肿瘤患者的外周血。采用PCR-RFLP技术对样本中的FSHR基因第10外显子Ala307Thr进行基因分型检测。结果 FSHR基因第10外显子Ala307Thr在浆液性卵巢癌患者组和对照组之间的基因型分布存在显著差异(P=0.000 4),经年龄调整后两组的307Ala携带率有显著性差异(P=0.001),OR值为6.525(95%CI=2.202～19.335)。结论 FSHR基因第10外显子Ala307Thr与浆液性卵巢癌的发病风险相关,307Ala携带可能会增加浆液性卵巢癌的发病风险。Objective To investigate the relationship between the SNP Ala307Thr in follicle stimulating hormone receptor （FSHR） exon 10 and the susceptibility of ovarian serous cancer. Methods In this case-control study,ovarian tissues were collected from 48 patients with ovarian serous cancer and peripheral blood samples from 30 women without gynecological malignant tumors as control. By PCR-RFLP, genotyping analyses were performed on Ala307Thr in FSHR exon 10. Results The distribution of three genotypes of FSHR Ala307Thr （Thr/Thr, Ala/Thr and Ala/Ala） was statistically different between the case and control groups （P = 0. 000 4）. And the rate of 307Ala carriers was significantly different in two the groups after age was adjusted （P = 0. 001 ,OR = 6. 525, 95%CI： 2. 202 - 19. 335）. Conclusions Ala307Thr in FSHR exon 10 correlated with the susceptibility of ovarian serous cancer. 307Ala carriers were associated with significantly increased the risk of development of ovarian serous cancer.

关 键 词：卵巢癌 促卵泡激素受体 单核苷酸多态性 限制性片段长度多态性 

分 类 号：R711.75[医药卫生—妇产科学]