红花黄色素抗大鼠急性心肌缺血研究  

The experimental study of carithamine on myocardial ischemia

作　　者：齐越[1] 秦文艳[1] 宋达夫[1] 刘禾[1] 赵金明[1] 

机构地区：[1]辽宁中医药大学附属第二医院,沈阳110034

出　　处：《中药药理与临床》2012年第5期21-23,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察红花黄色素对大鼠实验性心肌缺血的影响。方法:大鼠舌下静脉注射垂体后叶素(Pit)1u/kg制备急性心肌缺血模型,观察红花黄色素对大鼠心肌缺血百分率的影响;大鼠皮下注射盐酸肾上腺素0.8mg/kg加冰水刺激复制大鼠急性血瘀证模型,观察红花黄色素对急性血瘀证大鼠血液流变性的影响;小鼠常压耐缺氧实验,观察红花黄色素对小鼠耐缺氧能力的影响。结果:红花黄色素18、9、4.5 mg/kg舌下静脉给药能显著对抗Pit致大鼠心肌缺血百分率;降低"血瘀症"模型大鼠的全血比黏度、血浆比黏度、红细胞压积及纤维蛋白原含量;明显延长小鼠常压耐缺氧时间。结论:红花黄色素对大鼠急性心肌缺血具有保护作用,其作用与降低缺血百分率,改善血液流变学和减少心肌耗氧等有关。Objective：To study the effect of carithamine on experimental myocardial ischemia.Methods：By ranine vein injection pituitary creates rats myocardial ischemia（1u/kg）,to observe the effect of carithamine on the myocardial ischemia percentage in rats;0.8 mg/kg adrenaline was administrated by subcutaneous injection to establish rat blood stasis model;the tolerance experiment of mouse under normal pressure.Results：Carithamine（18、9、4.5 mg/kg） markedly decreased the myocardial ischemia percentage,could obviously reduce the blood viscosity in blood stasis model,also can prolong the mouse＇s survival time in hypoxia.Conclusions：Carithamine has protective action on acute experimental myocardial anoxia,and the effect is related to decrease myocardial ischemia percentage,improve the hemorheology,degrade oxygen consumption in cardiac muscle.

关 键 词：红花黄色素 心肌缺血 垂体后叶素 血液流变学 

分 类 号：R285[医药卫生—中药学]