艾叶水煎液外用对瘙痒及皮炎模型的影响  

External curative effect of Mugwort Water decoction in pruritus and dermatitis model

作　　者：苗晋鑫[1] 郭晓芳[1] 苗明三[1] 

机构地区：[1]河南中医学院,郑州450008

出　　处：《中药药理与临床》2012年第5期117-119,共3页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家"十一五"支撑计划(2008BAI53B09);郑州市科技攻关(10PTGS485-21)

摘　　要：目的:探讨艾叶水煎液外用对小鼠、豚鼠瘙痒及皮炎模型的影响。方法:艾叶水煎液外用对右旋糖酐致小鼠瘙痒模型的影响、对2,4-二硝基氯苯(DNCB)致小鼠接触性皮炎的影响、对磷酸组胺致豚鼠皮肤瘙痒模型的影响。结果:大、中、小剂量(0.75g/cm2、0.5 g/cm2、0.25 g/cm2)艾叶水煎液组均显著减少小鼠右旋糖酐所致的瘙痒次数、耳损伤程度、耳壳重量差、血清IL-4的含量,提高磷酸组胺致豚鼠瘙痒的阈值。结论:艾叶水煎液外用对小鼠、豚鼠瘙痒及皮炎模型有治疗作用。Objective：To explore the external curative effect of mugwort decoction in pruritus and dermatitis mice,guinea pigs model.Methods：Observe the decoction of mugwort water to the dextran in mice model of pruritus,the 2,4-dinitrochlorobenzene（DNCB） contact dermatitis in mice models,the phosphorylation of histamine induced itching model of guinea pig.Results：Large、middle、smalle（0.75g/cm2、0.5 g/cm2、0.25 g/cm2）mugwort water decoction can significantly reduce the number of dextran induced pruritus,damage of the right ear dermatitis in mice,weight value of auricular and serum levels of IL-4,improve the itching caused by histamine phosphate threshold in guinea pigs（P0.01）.Conclusion：Mugwort water decoction has remarkable external curative effect on pruritus and dermatitis mice,guinea pigs model.

关 键 词：艾叶 外用 瘙痒及皮炎模型 

分 类 号：R285[医药卫生—中药学]